Usage
This combination medication is primarily prescribed to manage capillary bleeding and reduce capillary fragility. It is classified as a hemostatic or antihemorrhagic agent.
Alternate Names
There isn’t a universally recognized international nonproprietary name (INN). It is often identified by its components. Brand names include Styptocid, Cadisper-C, and Styptocip.
How It Works
Pharmacodynamics:
- Adrenochrome monosemicarbazone: Promotes vasoconstriction and platelet aggregation, thereby reducing capillary fragility and controlling bleeding.
- Rutin: This bioflavonoid strengthens capillary walls and exhibits anti-inflammatory properties.
- Vitamin C (Ascorbic Acid): Enhances collagen synthesis, which is crucial for maintaining the integrity of blood vessels. It may also improve the absorption and effectiveness of the other ingredients.
Pharmacokinetics: Specific details on the combined formulation’s absorption, metabolism, and elimination are limited. The individual components have varying pharmacokinetic profiles.
Mechanism of Action: The combined action contributes to hemostasis by improving capillary resistance, promoting vasoconstriction, and aiding blood clotting.
Dosage
Dosage depends on the product and patient’s condition. Always consult the manufacturer’s instructions and seek professional medical advice.
Standard Dosage
Adults:
A typical adult dosage is 1-2 tablets three times daily. Some sources mention adrenochrome monosemicarbazone dosages ranging from 0.5 mg to 1 mg per tablet in combination with other ingredients.
Children:
Dosages for children should be determined by a physician based on the child’s weight and condition. Pediatric use requires caution.
Special Cases:
- Elderly Patients: Exercise caution due to potential age-related sensitivities.
- Patients with Renal Impairment: Dose adjustments may be necessary. Consult a physician.
- Patients with Hepatic Dysfunction: Dose adjustments may be necessary. Consult a physician.
- Patients with Comorbid Conditions: Careful evaluation is needed, especially for patients with conditions affecting blood clotting or those taking anticoagulants.
Clinical Use Cases
Specific dosage recommendations for these settings are not consistently available and should be determined by a physician:
- Intubation: Data not available.
- Surgical Procedures: One source mentions Styptocid injection pre- and post-operatively (1-2 ampules at 6-hour intervals).
- Mechanical Ventilation: Data not available.
- Intensive Care Unit (ICU) Use: Data not available.
- Emergency Situations: Data not available.
Dosage Adjustments
Adjustments may be required in cases of renal or hepatic impairment and for potential drug interactions. Consult a physician for specific guidance.
Side Effects
Common Side Effects
- Nausea
- Vomiting
- Diarrhea
- Rash
- Swelling
- Headache
- Dizziness
- Injection site reactions (pain, swelling, redness) - for injectable forms
Rare but Serious Side Effects
Clinically significant adverse reactions are rare, but allergic reactions should be monitored and treated if they occur.
Long-Term Effects
No specific long-term effects are consistently documented.
Adverse Drug Reactions (ADR)
Significant ADRs requiring immediate intervention are rare. Monitoring for allergic reactions is essential.
Contraindications
- Hypersensitivity to any of the components
- First trimester of pregnancy (as mentioned for Styptocid)
- Severe hepatic disease (as advised for Styptocip)
Drug Interactions
Specific interactions for this combination are not comprehensively documented. Consult a physician about potential interactions, especially with anticoagulants.
Pregnancy and Breastfeeding
Caution is advised during pregnancy and breastfeeding. Consult with a physician. Data on the specific combination are limited.
Drug Profile Summary
- Mechanism of Action: See “How It Works”
- Side Effects: See “Side Effects”
- Contraindications: See “Contraindications”
- Drug Interactions: See “Drug Interactions”
- Pregnancy & Breastfeeding: Caution is advised; consult a physician
- Dosage: See “Dosage”
- Monitoring Parameters: Monitor for bleeding, allergic reactions, and unusual side effects
Popular Combinations
This combination is typically prescribed as is. Data on other combinations are limited.
Precautions
- General Precautions: Screen for allergies, metabolic disorders, and organ dysfunction.
- Specific Populations: Consult a physician for guidance concerning pregnant or breastfeeding women, children, and the elderly.
- Lifestyle Considerations: Information on alcohol, smoking, or dietary restrictions is not consistently provided.
FAQs (Frequently Asked Questions)
Q1: What is the recommended dosage for Adrenochrome Monosemicarbazone + Rutin + Vitamin C?
A: The standard adult dosage is often 1-2 tablets three times a day. Pediatric and special population dosing must be determined by a physician.
Q2: What are the primary uses of this medication?
A: This combination is mainly used to manage capillary bleeding and reduce capillary fragility.
Q3: What is the mechanism of action of this combination?
A: Adrenochrome monosemicarbazone promotes vasoconstriction and platelet aggregation. Rutin strengthens capillaries, and vitamin C supports collagen synthesis for vessel integrity.
Q4: Are there any significant drug interactions?
A: Specific drug interactions are not fully documented, but caution is advised with anticoagulants. Consult a physician about potential interactions with other medications.
Q5: What are the common side effects?
A: Common side effects may include nausea, vomiting, diarrhea, rash, swelling, headache, and dizziness.
Q6: Is this medication safe during pregnancy and breastfeeding?
A: Caution is advised. Consult a physician due to limited data on the combination’s effects during pregnancy and breastfeeding.
Q7: Are there any contraindications to using this medication?
A: Contraindications include hypersensitivity to any component, the first trimester of pregnancy (as mentioned for Styptocid), and severe hepatic disease (as advised for Styptocip).
Q8: What precautions should be taken while using this medication?
A: Screen patients for allergies, metabolic disorders, and organ dysfunction. Exercise caution in elderly patients and those with renal or hepatic impairment. Consult a physician for appropriate dose adjustments.
Q9: How should this medication be stored?
A: Store at room temperature, away from light and moisture, and out of reach of children.
