Usage
This topical cream combines antiseptic, antibacterial, and healing properties. It is prescribed for the treatment and prevention of skin infections, particularly in burns (first-degree/superficial), minor cuts, wounds, sores, insect bites, rashes, abrasions, surgical cuts, leg ulcers, pressure sores, blisters, and cracked skin. It can also be used prophylactically at skin graft donor sites.
Pharmacological Classification: Antiseptic, antibacterial, wound healing agent.
Mechanism of Action: The cream exerts its therapeutic effects through the combined action of its individual components: Silver nitrate and Chlorhexidine gluconate act as antiseptics and antibacterial agents, eliminating a broad spectrum of bacteria. Aloe vera provides soothing and healing benefits, promoting skin regeneration and reducing inflammation. Allantoin functions as a keratolytic and moisturizing agent, softening the skin and facilitating tissue repair.
Alternate Names
- Silvacure+
- Burnosept Plus
- Other brand names may exist regionally.
How It Works
Pharmacodynamics: The combined effect of silver nitrate and chlorhexidine gluconate delivers a broad-spectrum antimicrobial action. Aloe vera and allantoin contribute to wound healing and diminish inflammation.
Pharmacokinetics: Topical application results in minimal systemic absorption. The components exert their primary action at the application site. The elimination pathways for the individual components have not been well established following combined topical use.
Mode of Action:
- Silver Nitrate: Releases silver ions that disrupt bacterial cell walls and membranes, leading to bacterial death.
- Chlorhexidine Gluconate: Binds to bacterial cell walls, disrupting their integrity and causing cell death.
- Aloe Vera: Contains various compounds with anti-inflammatory, antioxidant, and wound-healing properties. It promotes skin regeneration and reduces inflammation.
- Allantoin: Facilitates cell proliferation and tissue repair, contributing to wound healing. It also softens and moisturizes the skin.
Dosage
Standard Dosage
Adults: Apply a thin layer to the affected area 1-2 times daily or as directed by a physician.
Children: Apply a thin layer to the affected area 1-2 times daily or as directed by a physician. Pediatric safety considerations include avoiding application to large areas of broken skin in infants and young children due to the potential for systemic absorption of silver nitrate.
Special Cases:
- Elderly Patients: No specific dosage adjustments are typically required, but monitor for skin sensitivity.
- Patients with Renal Impairment: Dosage adjustment is not typically necessary due to minimal systemic absorption.
- Patients with Hepatic Dysfunction: Dosage adjustment is not typically necessary due to minimal systemic absorption.
- Patients with Comorbid Conditions: No specific adjustments are typically required, but consider individual patient factors.
Clinical Use Cases:
Dosage in clinical use cases generally aligns with the standard dosage recommendations. Specific adjustments may be made based on the severity and extent of the wound or burn.
- Intubation, Surgical Procedures, Mechanical Ventilation, Intensive Care Unit (ICU) Use, Emergency Situations: For topical antiseptic or wound care purposes, follow the standard dosage, adapting it to the specific clinical situation as needed.
Side Effects
Common Side Effects:
- Itching
- Redness
- Application site reactions (burning, irritation)
Rare but Serious Side Effects:
- Allergic reactions (e.g., rash, hives, swelling)
Long-Term Effects: No significant long-term adverse effects are expected with topical use.
Adverse Drug Reactions (ADR):
- Severe allergic reactions (rare)
Contraindications:
- Hypersensitivity to any of the components.
- Patients with known allergy to any of the ingredients, particularly silver nitrate and chlorhexidine.
Drug Interactions:
No significant drug interactions are known for topical application. However, inform your healthcare provider of all medications, supplements, and herbal products you are using.
Pregnancy and Breastfeeding:
Limited data are available regarding use during pregnancy and breastfeeding. Use with caution and consult a physician. If possible consider alternative treatment options with better established safety profiles in these specific populations.
Drug Profile Summary
- Mechanism of Action: Antiseptic, antibacterial, and wound healing.
- Side Effects: Itching, redness (rarely, allergic reactions).
- Contraindications: Hypersensitivity to any components.
- Drug Interactions: None known for topical application.
- Pregnancy & Breastfeeding: Use with caution; consult a physician.
- Dosage: Apply a thin layer 1-2 times daily or as directed.
- Monitoring Parameters: Observe for skin irritation or allergic reactions.
Popular Combinations:
Often used as a standalone product. May be combined with other topical wound care products as directed by a physician.
Precautions
- General Precautions: Avoid contact with eyes. Discontinue use if irritation persists. For external use only.
- Specific Populations: Monitor closely in pregnant/breastfeeding women.
- Lifestyle Considerations: No specific lifestyle restrictions.
FAQs (Frequently Asked Questions)
Q1: What is the recommended dosage for this cream?
A: Apply a thin layer to the affected area 1-2 times daily, or as directed by a physician.
Q2: Can this cream be used on children?
A: Yes, but avoid applying to large areas of broken skin in infants and young children due to the potential systemic absorption of silver nitrate. Consult a pediatrician.
Q3: What should I do if I experience side effects?
A: Discontinue use and consult your physician if you experience any allergic reactions or persistent irritation.
Q4: Can I use this cream if I am pregnant or breastfeeding?
A: Limited data are available; consult your physician before use.
Q5: How does this cream work?
A: The combination of silver nitrate and chlorhexidine provides antiseptic and antibacterial effects, while aloe vera and allantoin promote healing and soothe the skin.
Q6: Can this cream be used on open wounds?
A: Yes, this cream can be used on open wounds to help prevent infection and promote healing.
Q7: Are there any drug interactions I should be aware of?
A: No significant drug interactions are known for topical use. However, inform your physician of all medications you are currently taking.
Q8: How should I store this cream?
A: Store the cream in a cool, dry place away from direct sunlight and out of reach of children.
Q9: Is this cream safe for long-term use?
A: No significant long-term adverse effects are expected with topical use. However, consult your physician for extended use cases.
Q10: What should I do if the cream gets in my eyes?
A: Rinse the eyes thoroughly with water and consult a physician if irritation persists.
