Usage
Allantoin + Clotrimazole is prescribed for the treatment of fungal skin infections such as:
- Athlete’s foot (tinea pedis)
- Jock itch (tinea cruris)
- Ringworm (tinea corporis)
- Candida infections
- Fungal infections caused by excessive sweating
Pharmacological Classification: Antifungal and Skin Protectant
Mechanism of Action: Clotrimazole, an imidazole antifungal, inhibits ergosterol synthesis, a crucial component of the fungal cell membrane. This alters the membrane’s permeability, ultimately leading to fungal cell death. Allantoin, a skin protectant, moisturizes, softens, and promotes skin healing, while also enhancing clotrimazole’s penetration into the skin.
Alternate Names
Candid Gold Dusting Powder; Candid Gold Powder; F-Next Dusting Powder.
How It Works
Pharmacodynamics: Clotrimazole exerts its antifungal effect by targeting ergosterol synthesis, thereby disrupting the fungal cell membrane. Allantoin promotes skin healing and hydration.
Pharmacokinetics: The combination is applied topically. Clotrimazole’s absorption through the skin is minimal, with most of the drug remaining localized to the application site. Allantoin is also minimally absorbed. The small amounts absorbed are primarily metabolized in the liver and excreted by the kidneys. Specific details regarding receptor binding, enzyme inhibition, or neurotransmitter modulation are not relevant as the drug primarily acts locally.
Elimination Pathways: Primarily hepatic metabolism and renal excretion for the small amounts that are absorbed systemically.
Dosage
Standard Dosage
Adults: Apply a thin layer to the affected area twice daily, gently massaging until absorbed. Treatment typically lasts 2-4 weeks, depending on the infection.
Children: Use in children should be directed by a physician, with dosage adjusted based on age and weight. Safety and efficacy in children under 2 years of age have not been established. For vaginal candidiasis in children, consult a healthcare professional for guidance.
Special Cases:
- Elderly Patients: No specific dosage adjustments are typically required.
- Patients with Renal Impairment: No specific adjustments needed.
- Patients with Hepatic Dysfunction: No specific adjustments needed.
- Patients with Comorbid Conditions: Dosage adjustments may be necessary; consult a physician.
Clinical Use Cases
Allantoin + Clotrimazole is intended for topical treatment of fungal skin infections. It is not indicated for systemic use and therefore not relevant in clinical settings such as intubation, surgical procedures, mechanical ventilation, ICU use, or emergency situations.
Dosage Adjustments
No specific dosage adjustments are generally necessary beyond those mentioned under “Special Cases.”
Side Effects
Common Side Effects:
- Burning or stinging sensation
- Itching
- Redness
- Skin peeling or dryness
- Rash or hives
Rare but Serious Side Effects: Severe allergic reactions (e.g., difficulty breathing, swelling of the face, lips, tongue, or throat).
Long-Term Effects: No significant long-term adverse effects have been reported with topical use.
Adverse Drug Reactions (ADR): As above under “Rare but Serious Side Effects.”
Contraindications
- Hypersensitivity to allantoin or clotrimazole.
Drug Interactions
May interact with topical corticosteroids (e.g., clobetasone, hydrocortisone) and retinoids (e.g., tretinoin). Concomitant use with other topical medications on the affected area should be discussed with a healthcare professional.
Pregnancy and Breastfeeding
Use only if clearly needed and under the supervision of a physician. It is not recommended for use in breastfeeding women unless absolutely necessary. Discuss risks and benefits with a doctor before using.
Drug Profile Summary
- Mechanism of Action: Clotrimazole inhibits ergosterol synthesis, disrupting fungal cell membranes. Allantoin promotes skin healing and hydration.
- Side Effects: Burning, stinging, itching, redness, peeling, dryness, rash. Rarely, severe allergic reactions.
- Contraindications: Hypersensitivity to allantoin or clotrimazole.
- Drug Interactions: Topical corticosteroids, retinoids.
- Pregnancy & Breastfeeding: Use with caution if clearly needed and under medical supervision.
- Dosage: Apply a thin layer twice daily for 2-4 weeks.
- Monitoring Parameters: Monitor the affected area for signs of improvement or adverse reactions.
Popular Combinations
While Allantoin + Clotrimazole itself is a combination product, further combining it with other topical agents is generally not recommended without medical advice.
Precautions
Screen for allergies to allantoin or clotrimazole. Exercise caution in patients with sensitive skin. Avoid contact with eyes and mucous membranes. Pregnant or breastfeeding women should consult their physician.
FAQs (Frequently Asked Questions)
Q1: What is the recommended dosage for Allantoin + Clotrimazole?
A: Apply a thin layer to the affected skin twice daily for 2-4 weeks. Pediatric dosages should be determined by a physician.
Q2: How does Allantoin + Clotrimazole work?
A: Clotrimazole kills fungi by inhibiting ergosterol synthesis, a crucial part of the fungal cell membrane. Allantoin aids in skin healing and moisturizing.
Q3: What are the common side effects?
A: Common side effects include mild burning, stinging, itching, redness, dryness, and peeling. Severe allergic reactions are rare.
Q4: Can I use this during pregnancy or breastfeeding?
A: Consult your doctor before use during pregnancy or breastfeeding. Use only if clearly needed and under medical supervision.
Q5: What if I miss a dose?
A: Apply the missed dose as soon as you remember. Do not apply a double dose.
Q6: How long does treatment typically last?
A: Treatment typically lasts 2-4 weeks, but consult your doctor if the infection persists.
Q7: What should I do if my condition worsens?
A: Consult your doctor immediately if your symptoms worsen or do not improve after 2-4 weeks of treatment.
Q8: Can I use this on my face?
A: While generally safe, avoid applying to the face, especially near the eyes and mucous membranes, unless specifically directed by a physician. Use a product specifically formulated for facial use.
Q9: Can this be used for diaper rash?
A: While effective against Candida, diaper rash can have other causes. Consult a pediatrician for diagnosis and appropriate treatment.
