Usage
This topical medication is primarily used as a moisturizer to treat dry, rough, and chapped skin. It is indicated for conditions such as xerosis, ichthyosis, hyperkeratosis, eczema, psoriasis, and dermatitis. It can also provide relief from minor burns, insect bites, and diaper rash.
Pharmacological Classification: Topical emollient and humectant.
Mechanism of Action: Urea and lactic acid work synergistically. Urea is a humectant, drawing moisture into the skin and softening keratin. Lactic acid is both a keratolytic and humectant, exfoliating and moisturizing the skin. The other ingredients provide additional moisturizing, soothing, and electrolyte support to the skin.
Alternate Names
Ceracue Cream, Cotaryl Cream, Remoiz Cream.
How It Works
Pharmacodynamics: The cream primarily exerts its effects through the humectant and keratolytic properties of urea and lactic acid. Urea increases skin hydration by drawing water from the deeper layers of the skin and the atmosphere. Lactic acid promotes exfoliation by breaking down the bonds between dead skin cells, leading to smoother and softer skin. Additionally, lactic acid contributes to hydration. Other components like glycine, calcium lactate, magnesium chloride, potassium chloride, sodium chloride, and sodium dihydrogen phosphate dihydrate contribute to maintaining the skin’s electrolyte balance and provide further moisturizing effects.
Pharmacokinetics: The cream is applied topically, and absorption is mainly localized to the application site. Minimal systemic absorption is expected with intact skin. However, with damaged or broken skin, some systemic absorption of urea may occur. Urea is primarily excreted renally, while lactic acid is metabolized in the liver. The pharmacokinetics of other components are not clinically significant for topical application.
Dosage
Standard Dosage
Adults: Apply a thin layer to the affected area two to three times daily, or as directed by a physician. Gently massage until absorbed.
Children: Consult a pediatrician for appropriate dosing in children as safety and efficacy in pediatric patients haven’t been extensively established.
Special Cases:
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Elderly Patients: No specific dosage adjustments are typically required.
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Patients with Renal Impairment: Caution is advised, and patients should be monitored for systemic absorption, particularly urea.
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Patients with Hepatic Dysfunction: No specific dosage adjustments are necessary.
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Patients with Comorbid Conditions: Consider individual patient needs and monitor for any adverse reactions.
Clinical Use Cases
This cream is generally not used in clinical settings such as intubation, surgical procedures, mechanical ventilation, ICU, or emergency situations.
Side Effects
Common Side Effects:
Mild and transient irritation, burning, or itching at the application site.
Rare but Serious Side Effects:
Allergic reactions, such as redness, swelling, or hives.
Contraindications
Known hypersensitivity to any of the ingredients in the cream. Use with caution on broken or damaged skin due to the potential for increased systemic absorption of urea.
Drug Interactions
No significant drug interactions are expected with topical application.
Pregnancy and Breastfeeding
Insufficient data are available regarding the safety of this combination cream during pregnancy and breastfeeding. Consult a physician before using during pregnancy or while breastfeeding.
Drug Profile Summary
- Mechanism of Action: Urea and lactic acid act as humectants and keratolytics, improving skin hydration and exfoliation.
- Side Effects: Generally well-tolerated, although mild skin irritation may occur.
- Contraindications: Hypersensitivity to any ingredients.
- Drug Interactions: No significant interactions expected.
- Pregnancy & Breastfeeding: Consult a physician before use.
- Dosage: Apply thinly to affected area two to three times daily.
- Monitoring Parameters: Monitor for local skin reactions.
Popular Combinations
No specific popular combinations are typically associated with this cream.
Precautions
- General Precautions: Discontinue use if irritation develops. Avoid contact with eyes.
- Specific Populations: No specific precautions beyond the general recommendations.
FAQs (Frequently Asked Questions)
Q1: What is the recommended dosage for Ammonium Chloride + Calcium Lactate + Glycine + Lactic Acid + Magnesium Chloride + Potassium Chloride + Sodium Chloride + Sodium Dihydrogen Phosphate Dihydrate + Urea cream?
A: Apply a thin layer to the affected area two or three times a day, or as directed by your physician.
Q2: Can this cream be used on the face?
A: Yes, it can be used on the face, but avoid the area around the eyes.
Q3: Is it safe to use this cream during pregnancy?
A: Consult a physician before using this cream during pregnancy or while breastfeeding, as there is limited data available.
Q4: Can this cream be used on children?
A: Consult a pediatrician before using on children.
Q5: What should I do if I experience skin irritation after using the cream?
A: Discontinue use and consult a physician or dermatologist.
Q6: How does urea work in this cream?
A: Urea acts as a humectant, drawing moisture into the skin and softening the keratin.
Q7: Can I use this cream if I have eczema?
A: Yes, this cream can be used to help manage dry skin associated with eczema. However, consult a dermatologist for proper diagnosis and treatment recommendations.
Q8: What is the role of lactic acid in this cream?
A: Lactic acid is a keratolytic and humectant, meaning it helps exfoliate the skin and also contributes to moisturizing.
Q9: Is it okay to use this cream with other skincare products?
A: Generally, yes, but consult a physician or dermatologist for specific recommendations based on your individual skincare routine and any other medical conditions.
