Usage
This combination of probiotics is primarily prescribed for managing various gastrointestinal disorders, including:
- Dysbacteriosis (imbalance of gut flora)
- Antibiotic-associated diarrhea
- Infectious diarrhea
- Gastroenteritis
- Inflammatory bowel disease (IBD)
- Constipation
- Clostridium difficile-associated diarrhea
- Helicobacter pylori infection
- Traveler’s diarrhea
- Diarrhea in pregnant women
- Lactose intolerance
It may also be used for conditions like allergic disorders, obesity, common cold, eczema, inflammatory arthritis, vaginal yeast infections, and urinary tract infections, although more research is needed for these uses.
Pharmacological Classification: Probiotic
Mechanism of Action: This combination product works by restoring and maintaining the balance of beneficial bacteria in the gut. Each component contributes in specific ways:
- Bacillus mesentericus inhibits the growth of some harmful bacteria.
- Clostridium butyricum produces butyric acid, an important energy source for the cells lining the gut.
- Lactic acid bacillus produces lactic acid, which helps maintain a healthy pH balance in the gut.
- Streptococcus faecalis T-110 JPC assists in breaking down carbohydrates and also produces lactic acid.
Alternate Names
There are no widely recognized alternate names for this specific combination product. Individual components may be referred to by other names (e.g., Enterococcus faecalis for Streptococcus faecalis).
Brand Names: Several brand names exist for this combination, including Cronogut, Synerbact, Bifilac, Azbiotic, Grinedgut, and others depending on the manufacturer and region.
How It Works
Pharmacodynamics: The combined action of the four probiotics helps restore a healthy gut microbiome, which positively influences various physiological processes. It can reduce inflammation in the gut, improve nutrient absorption, and enhance immune function. Butyric acid produced by C. butyricum is crucial for gut health, acting as an energy source for colonocytes and promoting the growth of beneficial bacteria.
Pharmacokinetics: These probiotics primarily exert their effects within the gastrointestinal tract. Bacillus mesentericus spores are resistant to stomach acid, allowing them to reach the intestines. Information on the specific pharmacokinetics (absorption, distribution, metabolism, excretion) of each component is limited. As live microorganisms, they colonize the gut, reproduce, and their metabolic byproducts contribute to the overall effects. Elimination mostly occurs through the feces.
Mode of Action: The probiotics in this combination modulate the gut flora by competing with pathogenic bacteria for resources and adhesion sites, thereby limiting the growth of harmful microorganisms. The production of lactic acid and butyric acid creates an unfavorable environment for the growth of certain pathogenic bacteria. The probiotic bacteria also enhance immune function by stimulating the activity of gut-associated lymphoid tissue (GALT).
Dosage
Dosage guidelines vary depending on the specific product formulation and the patient’s condition. Consulting a doctor for appropriate dosage recommendations is essential. Always check the product labeling.
Standard Dosage
Children: Pediatric dosage must be determined by a pediatrician, considering factors like age, weight, and the child’s specific health condition.
Special Cases: Dosage modifications might be necessary in these cases. Consult a physician.
- Elderly Patients: Insufficient data are available for specific dose adjustments.
- Patients with Renal Impairment: Data are limited. Dose adjustments should be based on clinical evaluation.
- Patients with Hepatic Dysfunction: Similar to renal impairment, dose adjustments should be made based on the patient’s condition.
- Patients with Comorbid Conditions: Consult a physician.
Clinical Use Cases
The available sources do not specify dosage recommendations for these specific clinical settings. This product is primarily used for managing gastrointestinal disorders. Consult a specialist for guidance in these settings.
- Intubation
- Surgical Procedures
- Mechanical Ventilation
- Intensive Care Unit (ICU) Use
- Emergency Situations
Dosage Adjustments
Dosage modifications should be made at the physician’s discretion, considering renal and hepatic function, metabolic disorders, and other relevant factors.
Side Effects
Common Side Effects:
- Gas
- Bloating
- Abdominal discomfort
- Nausea
- Loss of appetite
- Constipation
- Diarrhea
- Flatulence
These side effects are typically mild and transient, resolving spontaneously within a few days.
Rare but Serious Side Effects:
In rare cases, particularly in individuals with compromised immune systems, probiotics could potentially cause infections.
Long-Term Effects:
Information regarding potential long-term side effects is limited.
Adverse Drug Reactions (ADR):
Clinically significant ADRs are rare but should be addressed immediately.
Contraindications
- Hypersensitivity to any component of the formulation.
- Critically ill patients.
- Patients with short bowel syndrome (due to the risk of bacterial translocation).
Drug Interactions
- Antibiotics: Antibiotics can reduce the efficacy of probiotics. It’s generally advised to administer them at least two hours apart.
- Consult your physician regarding other potential drug interactions.
Pregnancy and Breastfeeding
The safety of this combination product during pregnancy and breastfeeding has not been fully established. Consulting a physician before use during these periods is crucial.
Drug Profile Summary
- Mechanism of Action: Modulates gut flora, produces lactic acid and butyric acid, improves digestion, and can have immunomodulatory effects.
- Side Effects: Gas, bloating, abdominal discomfort, nausea, constipation, diarrhea. Rarely, infections.
- Contraindications: Hypersensitivity, critically ill patients, short bowel syndrome.
- Drug Interactions: Antibiotics.
- Pregnancy & Breastfeeding: Consult a physician before use.
- Dosage: Varies widely based on formulation and individual patient needs. Consult product labeling or physician.
- Monitoring Parameters: Monitor for resolution of gastrointestinal symptoms.
Popular Combinations
This combination itself represents a mix of commonly used probiotics. Combining it with other drugs requires careful consideration by a physician, depending on the patient’s condition.
Precautions
- Consult a physician before using in patients with weakened immune systems, malnutrition, or liver or kidney problems.
- Caution in patients with underlying severe gastrointestinal conditions.
- Monitor for persistent or worsening side effects.
FAQs (Frequently Asked Questions)
Q1: What is the recommended dosage for Bacillus mesentericus TO-A JPC + Clostridium butryricum TO-A + Lactic acid bacillus + Streptococcus faecalis T-110 JPC?
A: The dosage varies depending on the product formulation. Always follow the instructions on the product label or consult a physician.
Q2: Can I take this probiotic with antibiotics?
A: It’s generally recommended to separate the administration of probiotics and antibiotics by at least two hours, as antibiotics can reduce the effectiveness of the probiotic.
Q3: What is the role of this probiotic combination in gut health?
A: This combination aids in restoring and maintaining the balance of beneficial bacteria in the gut. It helps maintain a healthy pH level in the intestine and supports the digestion of carbohydrates. It also may help reduce intestinal inflammation.
Q4: Are there any serious side effects associated with this probiotic combination?
A: This combination is generally considered safe, but in rare cases, particularly in individuals with compromised immune systems, it could potentially cause infections.
Q5: Is this probiotic combination safe during pregnancy?
A: The safety of this probiotic during pregnancy and breastfeeding has not been fully established. It’s crucial to consult a physician before use.
Q6: How does this probiotic combination differ from other probiotics?
A: This combination contains specific strains that offer particular benefits, including aiding in digestion, reducing inflammation, and restoring healthy gut flora. The specific benefits may differ from other probiotic strains.
Q7: How long should I take this probiotic combination?
A: The duration of use should be determined by your physician, based on your specific health condition.
Q8: Can children take this probiotic combination?
A: Children can take this probiotic combination, but the dosage and suitability should be determined by a pediatrician.
Q9: What should I do if I experience side effects while taking this probiotic combination?
A: Mild side effects like gas and bloating are common. If you experience more severe or persistent side effects, discontinue use and consult your physician.
