Usage
This combination is primarily used as a dietary supplement to address nutritional deficiencies. It may be prescribed for conditions like diabetic neuropathy, carnitine deficiency, or pyridoxine deficiency. It supports overall health and wellness by improving nerve function and energy production. It is not classified under a single pharmacological class but acts as a nutritional supplement.
Alternate Names
- Coenzyme Q10 + Pyridoxine + Levocarnitine + Resveratrol + Benfotiamine
- CoQ10 + Vitamin B6 + L-carnitine + Resveratrol + Benfotiamine
- Agenon (brand name)
- Ageless Tablet
- Aisa Tablet
How It Works
This combination works synergistically through its individual components:
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Coenzyme Q10 (CoQ10): This is an antioxidant that plays a crucial role in mitochondrial electron transport chain, thereby promoting energy production. It also improves blood pressure and vascular function.
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Vitamin B6 (Pyridoxine): This is essential for brain function, nerve health, and red blood cell production. It is also involved in protein, fat, and carbohydrate metabolism.
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Levo-carnitine: This facilitates fatty acid transport into the mitochondria for energy production and can improve heart function and reduce fatigue.
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Resveratrol: This potent antioxidant and anti-inflammatory agent protects against cellular damage and reduces inflammation.
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Benfotiamine: A fat-soluble form of vitamin B1 (thiamine), benfotiamine improves nerve function, and reduces symptoms of diabetic neuropathy, and supports energy production.
Pharmacokinetics: The pharmacokinetics of this combination haven’t been specifically studied. However, the individual components have distinct pharmacokinetic profiles: CoQ10 is absorbed from the gut and transported via lipoproteins, while vitamin B6 is readily absorbed and metabolized in the liver. Levocarnitine is absorbed in the small intestine, and resveratrol undergoes rapid metabolism in the liver. Benfotiamine exhibits better bioavailability than thiamine and is converted into thiamine pyrophosphate. Elimination pathways for each component vary (renal/hepatic excretion, metabolism by CYP enzymes).
Dosage
Dosage varies depending on individual patient needs and product formulation. Consult product packaging or a healthcare professional for precise instructions.
Standard Dosage
Adults: A standardized dosage is not universally established. Refer to specific product labeling. A common recommendation is one tablet/capsule daily, but this can vary.
Children: Safety and efficacy haven’t been established in children. Consult a pediatrician before administration.
Special Cases:
- Elderly Patients: Dosage adjustments may be necessary due to age-related physiological changes.
- Patients with Renal Impairment: Dose adjustments may be needed; administer with caution.
- Patients with Hepatic Dysfunction: Dose adjustments may be needed; administer with caution.
- Patients with Comorbid Conditions: Careful consideration and consultation with a physician are necessary for patients with conditions like diabetes, cardiovascular disease, or bleeding disorders.
Clinical Use Cases
This combination is not typically used in clinical settings like intubation, surgical procedures, mechanical ventilation, ICU, or emergency situations.
Dosage Adjustments
Adjustments should be based on individual patient factors, including renal/hepatic function and other medical conditions.
Side Effects
Common Side Effects
Loss of appetite, heartburn, nausea, and vomiting.
Rare but Serious Side Effects
Information not available from sources used.
Long-Term Effects
Information not available from sources used.
Adverse Drug Reactions (ADR)
Information not available from sources used.
Contraindications
Known hypersensitivity to any of the components. Use with caution in patients with bleeding disorders as resveratrol may increase bleeding risk.
Drug Interactions
Resveratrol might interact with anticoagulants and antiplatelet medications. Consult a healthcare professional for potential interactions with other medications, including OTC drugs and supplements. Alcohol, certain medications, and conditions like thyroid disorders may affect vitamin B6 levels.
Pregnancy and Breastfeeding
Consult a healthcare professional before use during pregnancy or breastfeeding as safety hasn’t been established.
Drug Profile Summary
- Mechanism of Action: Synergistic action of components for nutritional support, nerve function, energy production, antioxidant and anti-inflammatory effects.
- Side Effects: Generally well-tolerated, but gastrointestinal issues may occur.
- Contraindications: Hypersensitivity to any component, use with caution in bleeding disorders.
- Drug Interactions: Potential interactions with anticoagulants and antiplatelet medications.
- Pregnancy & Breastfeeding: Consult a healthcare professional before use.
- Dosage: Varies; consult product labeling or a healthcare professional.
- Monitoring Parameters: None specifically identified.
Popular Combinations
No specific popular drug combinations were identified for this combination itself. However, individual ingredients may be combined with other drugs based on specific therapeutic needs (e.g., benfotiamine with other B vitamins for diabetic neuropathy).
Precautions
- General Precautions: Pre-screening for allergies or underlying medical conditions.
- Specific Populations: Consult healthcare professional for use in pregnant/breastfeeding women and children.
FAQs (Frequently Asked Questions)
Q1: What is the recommended dosage for Benfotiamine + Coenzyme Q10 + Levo-carnitine + Resveratrol + Vitamin B6?
A: Dosage varies by product and individual patient needs. Consult a healthcare professional or the product packaging for guidance.
Q2: Can this combination be used during pregnancy or breastfeeding?
A: Safety during pregnancy or breastfeeding has not been established. Consult with a healthcare professional.
Q3: Are there any known drug interactions?
A: Potential interaction exists with anticoagulants/antiplatelet medications due to the resveratrol component. Consult with a healthcare professional regarding potential interactions.
Q4: What are the common side effects?
A: Some individuals may experience gastrointestinal side effects like heartburn, nausea, or vomiting.
Q5: What is the mechanism of action of this combination?
A: The components work synergistically to improve nerve function, boost energy production, and provide antioxidant and anti-inflammatory benefits.
Q6: Is this combination appropriate for children?
A: The safety and efficacy of this combination in children haven’t been established. Consult a pediatrician.
Q7: How should this combination be taken?
A: Specific administration guidelines will vary by product. Commonly, they are administered orally with or without food. Follow the instructions provided by the manufacturer or your healthcare professional.
Q8: What should I do if I miss a dose?
A: Take the missed dose as soon as you remember. If it is close to the time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose to catch up.
Q9: Can I stop taking this combination if I feel better?
A: Consult your doctor before discontinuing any supplement, including this one. They can advise you on the best course of action based on your individual circumstances.
