Usage
- This combination is primarily prescribed as a dietary supplement to address nutritional deficiencies, particularly those related to thiamine (vitamin B1), carnitine, and vitamin B6. It may also be used to support nerve health and improve energy levels. Conditions it may be used for include carnitine deficiency, pyridoxine deficiency, and diabetic neuropathy. It can also be used as an adjunctive treatment for conditions such as high cholesterol, heart disease, and cancer.
- Pharmacological Classification: This combination is classified as a nutritional supplement. It does not fall under a single drug class like antibiotics or analgesics. Each component has its own pharmacological classification. Benfotiamine is a vitamin, Levo-carnitine is classified under amino acids, Resveratrol is an antioxidant, and Vitamin B6 is a vitamin.
- Mechanism of Action: This combination works by replenishing essential nutrients and supporting various metabolic processes. Benfotiamine, a fat-soluble form of vitamin B1, improves thiamine uptake and utilization, supporting nerve function. Levo-carnitine facilitates fatty acid transport into mitochondria, enhancing energy production. Resveratrol acts as an antioxidant, protecting cells from damage and potentially reducing inflammation. Vitamin B6 is essential for various metabolic processes, including nerve function and red blood cell formation.
Alternate Names
- This combination is commonly referred to by the names of its individual components. This combination does not have other international non-proprietary names (INNs).
- Brand Names: Ageless, Aisa, Agenon.
How It Works
- Pharmacodynamics: Benfotiamine improves nerve function by increasing thiamine levels in nerve tissues. Levo-carnitine improves energy production by facilitating fatty acid oxidation in mitochondria. Resveratrol exerts antioxidant and anti-inflammatory effects. Vitamin B6 is a cofactor for various enzymes involved in metabolism.
- Pharmacokinetics:
- Absorption: Benfotiamine is absorbed from the gastrointestinal tract. Levo-carnitine is absorbed primarily in the small intestine. Resveratrol absorption occurs mainly in the small intestine. Vitamin B6 is readily absorbed in the jejunum.
- Metabolism: Benfotiamine is converted to thiamine. Levo-carnitine is not extensively metabolized, Vitamin B6 is mainly metabolized in the liver and is excreted through kidneys. Resveratrol is quickly metabolized and has very low bioavailability.
- Elimination: Thiamine and its metabolites are primarily excreted in urine. Levo-carnitine is mainly eliminated by the kidneys.
- Mode of Action: Benfotiamine enhances transketolase activity, a key enzyme in the pentose phosphate pathway, thus protecting against the damaging effects of advanced glycation end products (AGEs). Levo-carnitine transports long-chain fatty acids into mitochondria for beta-oxidation, generating ATP. Resveratrol activates sirtuins, proteins involved in cellular health and longevity. Vitamin B6 acts as a coenzyme in various metabolic pathways.
- Receptor Binding, Enzyme Inhibition, Neurotransmitter Modulation: No specific receptor binding or neurotransmitter modulation has been described for this combination. Benfotiamine indirectly inhibits the formation of AGEs. Levo-carnitine interacts with carnitine acyltransferases.
- Elimination Pathways: Primarily renal excretion for all components.
Dosage
The dosage is dependent on the specific brand name or product being used.
Standard Dosage
Adults:
- One tablet per day, taken orally with or without food.
Children:
- Dosage for children should be determined by a pediatrician.
Special Cases:
- Elderly Patients: No specific adjustments are typically necessary.
- Patients with Renal Impairment: Dosage adjustments may be necessary.
- Patients with Hepatic Dysfunction: Consult a healthcare professional for dose adjustment.
- Patients with Comorbid Conditions: Dosage should be individualized based on the specific condition.
Clinical Use Cases
- Intubation: No specific dosage recommendations.
- Surgical Procedures: No specific dosage recommendations.
- Mechanical Ventilation: No specific dosage recommendations.
- Intensive Care Unit (ICU) Use: No specific dosage recommendations.
- Emergency Situations: No specific dosage recommendations.
Dosage Adjustments:
- Adjustments should be made for patients with renal or hepatic impairment.
Side Effects
Common Side Effects:
- Nausea
- Vomiting
- Heartburn
- Loss of appetite
- Diarrhea
- Skin rash
- Allergic reactions
- Dizziness
Rare but Serious Side Effects:
Long-Term Effects:
Adverse Drug Reactions (ADR):
- Severe allergic reactions.
Contraindications:
- Hypersensitivity to any of the components.
- Certain pre-existing medical conditions (e.g., diabetes, kidney or liver problems) may require caution.
Drug Interactions:
- Anticoagulants (e.g., warfarin, aspirin): Resveratrol might slow blood clotting.
- Anticonvulsants (e.g., phenytoin, phenobarbital): Vitamin B6 may reduce their effectiveness.
- Levodopa: Vitamin B6 can interfere with its efficacy.
- Altretamine: May interact with vitamin B6.
- Other nutritional supplements: Avoid concurrent use of multiple multivitamin products.
Pregnancy and Breastfeeding:
- Consult a healthcare professional before use during pregnancy or breastfeeding.
Drug Profile Summary
- Mechanism of Action: See above.
- Side Effects: See above.
- Contraindications: See above.
- Drug Interactions: See above.
- Pregnancy & Breastfeeding: Consult a healthcare professional.
- Dosage: See above.
- Monitoring Parameters: No specific monitoring parameters are routinely required for this combination.
Popular Combinations:
- Often combined with other B vitamins (e.g., B12).
Precautions:
- Consult a physician if you are taking other medications.
- Monitor for allergic reactions.
FAQs (Frequently Asked Questions)
Q1: What is the recommended dosage for Benfotiamine + Levo-carnitine + Resveratrol + Vitamin B6?
A: Standard adult dosage is typically one tablet per day, but it is crucial to consult with a healthcare professional or refer to the specific product packaging for precise instructions. Pediatric dosages should be determined by a pediatrician.
Q2: What are the common side effects of this combination?
A: Common side effects include nausea, vomiting, heartburn, loss of appetite, diarrhea, skin rash, and allergic reactions.
Q3: Are there any serious side effects?
A: Serious side effects are rare, but allergic reactions, including anaphylaxis, can occur.
Q4: Can this combination be used during pregnancy or breastfeeding?
A: Consult a healthcare professional before use during pregnancy or breastfeeding.
Q5: How does resveratrol contribute to this supplement’s effects?
A: Resveratrol acts as an antioxidant, protecting cells from damage and potentially reducing inflammation.
Q6: What is the role of Levo-carnitine in this combination?
A: Levo-carnitine facilitates fatty acid transport into mitochondria, enhancing energy production.
Q7: Can this supplement interact with other medications?
A: Yes, it can interact with anticoagulants, anticonvulsants, levodopa, altretamine, and other nutritional supplements.
Q8: Should patients with kidney or liver problems take this supplement?
A: Consult a healthcare professional for patients with these conditions, as dose adjustments may be necessary.
Q9: How long does it take for this supplement to show its effects?
A: The onset of effects can vary, but some individuals may notice improvements within a few weeks of consistent use.
Q10: What should a patient do if they miss a dose?
A: Take the missed dose as soon as possible, unless it is close to the next scheduled dose. Do not double the dose.
