Usage
Benzoxonium Chloride + Lidocaine is prescribed for the symptomatic treatment of mild mouth and throat infections, such as gingivitis, mouth ulcers (canker sores), stomatitis, pharyngitis, laryngitis, and sore throat associated with colds. It can also be used as an adjunctive therapy for tonsillitis.
Its pharmacological classifications include:
- Antiseptic: Benzoxonium chloride
- Local anesthetic: Lidocaine
Mechanism of Action: Benzoxonium chloride acts as an antiseptic, killing bacteria and other microorganisms. Lidocaine provides local pain relief by blocking nerve signals.
Alternate Names
There is no widely recognized international nonproprietary name (INN) for this fixed-dose combination. However, the individual components have the following INNs:
- Benzoxonium Chloride: Benzoxonium chloride
- Lidocaine: Lidocaine
Brand names may vary in different countries. Some examples include Orocil Lido and Lidocam.
How It Works
Pharmacodynamics:
- Benzoxonium Chloride: A quaternary ammonium compound that disrupts the cell membranes of bacteria, fungi, and some viruses, leading to their inactivation or death.
- Lidocaine: Blocks voltage-gated sodium channels in nerve cell membranes, inhibiting nerve impulse conduction and resulting in a localized loss of sensation.
Pharmacokinetics:
- Benzoxonium Chloride: Primarily acts locally with minimal systemic absorption. Data is available for a combination of benzoxonium/lidocaine product.
- Lidocaine: When applied topically in the mouth, some absorption may occur, although systemic levels are usually low. It is metabolized primarily in the liver and excreted by the kidneys.
Dosage
Standard Dosage
The dosage may vary depending on the specific product formulation (lozenges, spray, solution) and the severity of the infection. It’s crucial to follow the instructions provided by the doctor or on the product label.
Adults:
Dosages for adults vary based on formulation and indication. Check the particular product literature.
Children:
Use in children should be under the guidance of a physician. Some formulations are indicated for children over 4 years old, while others are contraindicated in children under a certain age, or specific dosage recommendations cannot be given for this age group.
Special Cases:
- Elderly Patients: No specific dosage adjustments are typically required but use with caution, as with any medication.
- Patients with Renal Impairment: Due to minimal systemic absorption, dosage adjustment is generally not needed.
- Patients with Hepatic Dysfunction: Lidocaine is metabolized in the liver, but with topical oral use, significant systemic levels are unlikely. However, caution is advisable in severe hepatic impairment.
- Patients with Comorbid Conditions: Consideration should be given to potential drug interactions and comorbid conditions, particularly cardiovascular disease.
Clinical Use Cases
Benzoxonium Chloride + Lidocaine is not typically used in clinical settings like intubation, surgical procedures, mechanical ventilation, or the ICU. Its use is primarily limited to the management of mild oral and throat infections.
Dosage Adjustments
Always refer to the specific product information and consult with a healthcare professional for guidance on dose adjustments.
Side Effects
Common Side Effects
- Burning sensation
- Dry mouth
- Metallic taste
- Temporary numbness
- Staining of teeth
Rare but Serious Side Effects
- Allergic reactions (rash, hives, itching, swelling, difficulty breathing)
Long-Term Effects
No long-term adverse effects have been specifically reported with the topical use of this combination. However, prolonged use (more than two weeks) is generally not recommended without medical supervision.
Adverse Drug Reactions (ADR)
Severe allergic reactions can occur, requiring immediate medical attention.
Contraindications
- Hypersensitivity to benzoxonium chloride, lidocaine, or any other component of the formulation.
- Severe burns or deep puncture wounds in the mouth.
Drug Interactions
Clinically significant drug interactions with topical Benzoxonium Chloride + Lidocaine are unlikely due to minimal systemic absorption. However, it is always best to inform your physician of all medications you are taking, including prescription, over-the-counter, and herbal products.
Pregnancy and Breastfeeding
The safety of Benzoxonium Chloride + Lidocaine during pregnancy and breastfeeding hasn’t been fully established. Consult a doctor before using this medicine if you are pregnant or breastfeeding. For benzoxonium/lidocaine product safety data is available.
Drug Profile Summary
- Mechanism of Action: Benzoxonium chloride: Antiseptic; Lidocaine: Local anesthetic.
- Side Effects: Burning sensation, dry mouth, metallic taste, temporary numbness, teeth staining.
- Contraindications: Hypersensitivity, severe burns, deep puncture wounds.
- Drug Interactions: Clinically significant interactions are unlikely.
- Pregnancy & Breastfeeding: Consult a doctor before use.
- Dosage: Varies depending on formulation; refer to product label or consult a doctor.
- Monitoring Parameters: Observe for local irritation or signs of allergic reaction.
Popular Combinations
Benzoxonium chloride and lidocaine are not commonly combined with other drugs in a single formulation for topical oral use.
Precautions
- Avoid contact with eyes.
- Do not swallow the product (unless specifically indicated for a particular formulation).
- Do not use for more than two weeks without medical supervision.
- Use cautiously in patients with wounds or lesions in the mouth.
- Inform your doctor if you have any allergies or medical conditions.
FAQs (Frequently Asked Questions)
Q1: What is the recommended dosage for Benzoxonium Chloride + Lidocaine?
A: The dosage varies depending on the formulation (lozenges, spray, solution) and the patient’s age. Please consult the product information or your doctor for specific dosing instructions.
Q2: Can I use this medication if I am pregnant or breastfeeding?
A: Consult your doctor before using this medication if you are pregnant or breastfeeding.
Q3: What should I do if I accidentally swallow the mouthwash?
A: If a significant amount is swallowed, seek medical attention immediately.
Q4: How long can I use this medication?
A: Do not use for more than two weeks without consulting your doctor.
Q5: Can I use this medication for severe mouth infections?
A: This medicine is intended for mild mouth and throat infections. Consult a doctor for severe infections.
Q6: What are the signs of an allergic reaction to this medication?
A: Allergic reactions can manifest as rash, hives, itching, swelling of the face, tongue, or throat, and difficulty breathing. Seek immediate medical attention if these occur.
A: It’s best to wait a short time after using the product before eating or drinking to allow the medication to work effectively.
Q8: Can I use this product if I have open sores in my mouth?
A: Use with caution if you have open sores or lesions in your mouth. Consult your doctor if you have any concerns.
Q9: What are the storage recommendations for this medication?
A: Store in a cool, dry place away from direct sunlight and out of reach of children. Refer to the product packaging for specific storage instructions.
