Usage
This combination is prescribed for the management and treatment of combined nutritional deficiencies of beta-carotene, copper, manganese, selenium, and zinc. It is also used as a therapeutic nutritional adjunct in conditions where the intake or absorption of vitamins and minerals is suboptimal. This might be in cases such as: malignancy, immune deficiency syndromes, malabsorption, inflammatory bowel disease, short bowel syndrome, Crohn’s disease, during convalescence from illness or surgery, patients on restricted diets, food intolerance, or when concurrent medication decreases vitamin and mineral absorption.
Pharmacological Classification: Nutritional Supplement, Antioxidant
Mechanism of Action: This combination replenishes deficient micronutrients. Beta-carotene converts to vitamin A, crucial for vision, immunity, and skin health. Copper, manganese, selenium, and zinc are cofactors for enzymes involved in antioxidant defense, bone health, immune function, and wound healing.
Alternate Names
Beta Carotene + Copper + Manganese + Selenium + Zinc Sulfate; Multivitamin/Multimineral Supplement; Antioxidant Formula. Some brand names include Dermoxid-HC Softgel Capsule and Glowishma Softgel Capsule.
How It Works
Pharmacodynamics: Beta-carotene acts as a precursor to vitamin A, an essential nutrient for cell growth and differentiation, vision, reproduction, and immune function. Copper is vital for iron metabolism, collagen formation, and nerve function. Manganese is involved in bone formation, wound healing, and metabolism. Selenium is crucial for thyroid hormone metabolism and antioxidant function. Zinc supports immune function, cell growth, and wound healing.
Pharmacokinetics: Absorption, metabolism, and elimination vary for each component. Beta-carotene is absorbed in the small intestine and converted to vitamin A. Copper is absorbed and transported by ceruloplasmin, while manganese absorption is limited. Selenium is readily absorbed and incorporated into selenoproteins. Zinc is absorbed in the small intestine and bound to proteins. Elimination pathways include renal and hepatic excretion.
Mode of Action: Beta-carotene acts as an antioxidant, protecting cells from free radical damage. Copper, manganese, selenium, and zinc are cofactors for various enzymes involved in metabolic processes. This may include receptor binding, enzyme activation, and neurotransmitter modulation.
Dosage
Dosage is individualized based on the specific deficiencies and patient factors. A healthcare professional should be consulted to determine the appropriate dosage.
Standard Dosage
Children: Dosage is determined by age, weight, and the specific deficiency. Consultation with a pediatrician is essential.
Special Cases: Dosage adjustments are made based on individual patient factors such as age, organ function, and comorbid conditions.
Clinical Use Cases
Dosage in specific clinical settings is determined by the patient’s nutritional needs and the severity of their condition. No specific dosage guidelines are available for this combination in situations like intubation, surgical procedures, mechanical ventilation, ICU use, or emergency situations.
Dosage Adjustments
Dose modifications may be necessary based on renal or hepatic dysfunction, metabolic disorders, or genetic polymorphisms affecting drug metabolism.
Side Effects
Common Side Effects
Nausea, vomiting, diarrhea, upset stomach, and yellowing of skin (with excessive beta-carotene intake).
Rare but Serious Side Effects
Allergic reactions, copper toxicity (with excessive intake).
Long-Term Effects
Potential long-term effects depend on the individual components and their dosages.
Adverse Drug Reactions (ADR)
Clinically significant ADRs are rare but may include gastrointestinal issues and allergic reactions.
Contraindications
Known hypersensitivity to any of the components. Caution is advised in patients with Wilson’s disease (copper accumulation) and hemochromatosis (iron overload).
Drug Interactions
Interactions may occur with certain medications, such as those affecting mineral absorption. Alcohol may interfere with the absorption of some nutrients.
Pregnancy and Breastfeeding
Consult with a healthcare professional before use during pregnancy and breastfeeding. Dosages should not exceed the recommended daily allowance.
Drug Profile Summary
- Mechanism of Action: Replenishes essential micronutrients. Beta-carotene converts to vitamin A. Copper, manganese, selenium, and zinc function as enzyme cofactors.
- Side Effects: Nausea, vomiting, diarrhea, upset stomach, skin yellowing.
- Contraindications: Hypersensitivity to any component, Wilson’s disease, hemochromatosis.
- Drug Interactions: Medications affecting mineral absorption, alcohol.
- Pregnancy & Breastfeeding: Consult a healthcare professional.
- Dosage: Individualized based on deficiency and patient factors.
- Monitoring Parameters: Nutrient levels, organ function.
Popular Combinations
This combination is often used alone. It can be combined with other vitamins and minerals as needed based on the specific deficiency profile.
Precautions
Screen for allergies, metabolic disorders, and organ dysfunction. Exercise caution in pregnant/breastfeeding women, children, and the elderly. Excessive intake of certain components may cause adverse effects.
FAQs (Frequently Asked Questions)
Q1: What is the recommended dosage for Beta Carotene + Copper Sulphate + Manganese + Selenium + Zinc Sulfate?
A: There’s no standard dosage. It is individualized based on specific deficiencies and patient factors. Consult a healthcare professional for guidance.
Q2: Can pregnant women take this combination?
A: Consult a doctor before use during pregnancy. Do not exceed recommended daily allowances.
Q3: What are the signs of zinc deficiency?
A: Impaired immune function, delayed wound healing, loss of appetite, hair loss, and skin lesions.
Q4: Are there any drug interactions with this combination?
A: Possible interactions exist with medications affecting mineral absorption. Inform your doctor about all medications you are taking.
Q5: Can this supplement be taken with food?
A: Yes, it can be taken with food to enhance absorption of some nutrients.
Q6: What are the benefits of selenium?
A: Selenium acts as an antioxidant, supports thyroid function, and boosts the immune system.
Q7: What is the role of manganese in the body?
A: Manganese contributes to bone health, wound healing, metabolism, and acts as an antioxidant.
Q8: What are the symptoms of copper deficiency?
A: Anemia, fatigue, weakness, and neurological problems.
Q9: How is this combination stored?
A: Store at room temperature away from moisture and heat.
