Usage
This combination of probiotics and a prebiotic (fructooligosaccharide) is primarily used to improve digestive health and restore the balance of gut flora. It is indicated for the prevention and treatment of various gastrointestinal issues, including antibiotic-associated diarrhea, infectious diarrhea (such as rotaviral diarrhea), traveler’s diarrhea, and irritable bowel syndrome (IBS). It may also be beneficial for other conditions like eczema and for improving semen parameters in men with varicocele.
- Pharmacological Classification: Probiotic, Prebiotic (Fructooligosaccharide)
- Mechanism of Action: Probiotics work by colonizing the gut and competing with harmful bacteria, thus promoting a healthy gut microbiome. They produce lactic acid, which lowers the pH of the intestine, creating an unfavorable environment for pathogenic bacteria. Fructooligosaccharides (FOS) act as prebiotics, providing nourishment for the beneficial bacteria, further enhancing their growth and activity in the gut.
Alternate Names
This specific combination does not have a widely recognized international non-proprietary name (INN). It is often referred to as a multi-strain probiotic or probiotic blend.
- Brand Names: This combination is available under various brand names. One example found in the sources is Florita LL. Due to constant changes in the pharmaceutical market, an up-to-date list of all brand names is not feasible.
How It Works
- Pharmacodynamics: The probiotics in this formulation exert their effects by competitively excluding pathogenic bacteria, producing antimicrobial substances (like lactic acid and bacteriocins), modulating the immune system, and enhancing the intestinal barrier function.
- Pharmacokinetics: Orally administered probiotics primarily reside in the gastrointestinal tract. They are not absorbed systemically in significant amounts. The viability of the probiotics is crucial for their efficacy and depends on factors such as gastric pH and bile acid concentration. FOS, being a prebiotic, is not digested by the human host but is fermented by the gut microbiota.
- Mode of Action: Probiotics compete for resources and adhesion sites within the gut, limiting the colonization of pathogenic bacteria. They also produce substances like lactic acid and bacteriocins that inhibit the growth of harmful microbes. FOS selectively promotes the growth of beneficial bacteria in the colon.
- Elimination Pathways: Probiotics are eliminated primarily through the feces. The byproducts of FOS fermentation, such as short-chain fatty acids, are absorbed and utilized by the host or further metabolized by the gut microbiota.
Dosage
Dosage varies depending on the product formulation and the specific condition being treated. Always refer to the manufacturer’s instructions and consult with a healthcare professional for appropriate dosing. The following information is derived from sources mentioning dosages for some of the individual components and should not be considered definitive for this specific combination product.
Standard Dosage
Adults:
Dosages found in sources for individual components range from billions to tens of billions of CFUs daily. Specific combinations might have different recommendations.
Children:
Pediatric doses must be determined based on the child’s age and weight, and under the guidance of a pediatrician. Sources report doses from six billion CFUs twice daily for infants to 37 billion CFUs daily for children 6 to 24 months old.
Special Cases:
Dosage adjustments may be necessary in the elderly, patients with renal or hepatic impairment, and those with comorbid conditions. Consult a healthcare professional for personalized advice.
Clinical Use Cases
Due to the limited information available, the usage in specific clinical settings for this particular formulation cannot be comprehensively described. Consult medical literature for specific indications and dosing recommendations.
Dosage Adjustments
Dose adjustments should be made on a case-by-case basis, considering patient-specific factors.
Side Effects
Common Side Effects:
Mild and transient gastrointestinal symptoms like bloating, gas, and abdominal discomfort may occur, especially during initial use.
Rare but Serious Side Effects:
In immunocompromised individuals or those with severe underlying health conditions, probiotics may rarely cause systemic infections.
Long-Term Effects:
No significant long-term adverse effects have been reported with probiotic use.
Adverse Drug Reactions (ADR):
Rare cases of severe allergic reactions have been reported.
Contraindications
Individuals with a known hypersensitivity to any of the components should avoid this product. Use with caution in severely immunocompromised patients.
Drug Interactions
No specific drug interactions have been identified with this probiotic combination. However, it is always advisable to inform your doctor about all medications and supplements you are taking.
Pregnancy and Breastfeeding
Consult a healthcare professional before using this product during pregnancy or breastfeeding. Some studies suggest that specific probiotics can be beneficial during pregnancy and lactation, but it is important to discuss the use of this particular combination with a doctor.
Drug Profile Summary
- Mechanism of Action: Improves gut health, restores gut flora balance.
- Side Effects: Bloating, gas, abdominal discomfort (rarely, systemic infections or allergic reactions).
- Contraindications: Hypersensitivity to any component, severe immunocompromise.
- Drug Interactions: Limited information available, always consult with a healthcare professional.
- Pregnancy & Breastfeeding: Consult a healthcare professional before use.
- Dosage: Varies; refer to product instructions and consult a healthcare professional.
- Monitoring Parameters: Typically, no specific monitoring is required. Observe for gastrointestinal tolerance.
Popular Combinations
Information on popular combinations specifically for this multi-strain probiotic formulation is limited. Individual strains are often combined with other probiotics or prebiotics.
Precautions
Standard precautions apply. Caution is advised in patients with severe underlying illnesses or immunocompromised states.
FAQs (Frequently Asked Questions)
Q1: What is the recommended dosage for Bifidobacterium bifidum + Fructo Oligosaccharide + Lactobacillus Acidophilus + Lactobacillus Plantarum + Lactobacillus casei + Lactobacillus fermentum + Lactobacillus reuteri + Lactobacillus rhamnosus?
A: The dosage is dependent on the specific product formulation. Consult a healthcare professional or refer to the product labeling for specific instructions.
Q2: What are the key benefits of this particular combination of probiotics?
A: This blend aims to support gut health by combining multiple probiotic strains, each potentially contributing to a balanced microbiome. The inclusion of FOS enhances their growth and activity.
Q3: Can this product be used in children?
A: Pediatric use should be determined by a pediatrician, who can advise on appropriate dosing and safety considerations.
Q4: Are there any specific dietary restrictions while taking this probiotic?
A: Generally, no specific dietary restrictions are associated with this probiotic. However, a balanced diet rich in fiber is generally recommended for gut health.
Q5: Can this probiotic help with lactose intolerance?
A: Some strains in this blend, like Lactobacillus acidophilus, may help alleviate lactose intolerance symptoms, but it’s not a guaranteed treatment.
Q6: How long does it take to see the benefits of this probiotic?
A: The onset of benefits can vary depending on individual factors and the specific condition being addressed. Some individuals may experience improvement within a few days, while others might require a few weeks of consistent use.
Q7: Can I take this probiotic along with antibiotics?
A: It is often recommended to take probiotics during or after a course of antibiotics to help prevent antibiotic-associated diarrhea and restore the gut flora. However, timing and specific instructions should be clarified with a healthcare professional.
Q8: Can this probiotic be used during pregnancy?
A: Consult with a healthcare professional before using probiotics during pregnancy. While some strains may be considered safe, it is crucial to evaluate the specific product and individual circumstances.
Q9: What should I do if I experience side effects while taking this product?
A: Most side effects are mild and transient. If you experience any unusual or persistent symptoms, discontinue use and consult a healthcare professional.
