Boric Acid + Camphor + Carboxymethylcellulose + Chlorpheniramine Maleate + Menthol + Naphazoline

Usage

This combination medication was primarily used as an ophthalmic solution for symptomatic relief of allergic conjunctivitis and eye irritation. This fixed-dose combination has been banned in India. The information below is provided for historical context and should not be interpreted as a recommendation for use.

It addressed various aspects of ocular discomfort:

• Naphazoline: A vasoconstrictor, it reduces redness and swelling.
• Chlorpheniramine Maleate: An antihistamine, it relieves itching and other allergic symptoms.
• Boric Acid: An antiseptic and buffering agent.
• Carboxymethylcellulose: A lubricant providing relief from dryness.
• Menthol and Camphor: Produce a cooling sensation.

Pharmacological Classification: Decongestant, antihistamine, lubricant, antiseptic.

Alternate Names

There’s no universally recognized non-proprietary name. It’s often identified by its components. Some brand names have included “Geezol Plus Eye Drops.” Regional variations existed before the ban.

How It Works

Pharmacodynamics: Naphazoline constricts conjunctival blood vessels, reducing redness and edema. Chlorpheniramine maleate competitively antagonizes histamine H1 receptors, mitigating allergic manifestations. Carboxymethylcellulose lubricates the ocular surface. Menthol and camphor provide a cooling sensation. Boric acid acts as a mild antiseptic and buffer.

Pharmacokinetics: Information on the combined formulation’s pharmacokinetics is limited. Individual components have distinct absorption, distribution, metabolism, and excretion profiles. Naphazoline, when applied topically, has minimal systemic absorption. Chlorpheniramine, though primarily topical, can have some systemic absorption. Boric acid, camphor, and menthol can also be absorbed systemically after topical ocular administration.

Mode of Action: Naphazoline acts on alpha-adrenergic receptors in the conjunctiva. Chlorpheniramine blocks the action of histamine at H1 receptors.

Dosage

This fixed-dose combination is banned in India, and no official dosage guidelines are available. The following is for informational purposes only and should not be interpreted as a recommendation.

Previously, the standard dosage involved 1-2 drops in the affected eye(s) every few hours. However, due to the ban, specific guidance is unavailable. Consult a doctor for appropriate alternatives.

Side Effects

Common side effects could include:

• Burning or stinging sensation
• Temporary blurred vision
• Pupil dilation
• Rebound congestion with overuse of naphazoline
• Dryness

Rare or serious side effects could include:

• Systemic effects of naphazoline (e.g., increased blood pressure, headache, tremor)
• Allergic reactions

Contraindications

Contraindications may have included:

• Hypersensitivity to any component
• Narrow-angle glaucoma
• Severe cardiovascular disease
• Hyperthyroidism

Drug Interactions

Potential interactions may have occurred with:

• MAO inhibitors
• Tricyclic antidepressants
• Beta-blockers

Pregnancy and Breastfeeding

The safety of this combination during pregnancy and breastfeeding was not well established. Consult a doctor for safe alternatives if pregnant or breastfeeding.

Drug Profile Summary

This combination product is banned in India. Information presented here is for historical context only and should not be used for treatment.

Popular Combinations

Not applicable due to the ban.

Precautions

Not applicable due to the ban.

FAQs (Frequently Asked Questions)

Q1: What is the recommended dosage for Boric Acid + Camphor + Carboxymethylcellulose + Chlorpheniramine Maleate + Menthol + Naphazoline?

A: This combination is banned in India. No dosage is recommended. Consult a physician for alternatives.

Q2: What conditions did this combination treat?

A: It was used for allergic conjunctivitis and eye irritation.

Q3: Why was this combination banned?

A: The reasons for the ban haven’t been provided in the current sources.

Q4: What are the alternatives to this combination?

A: Consult a doctor for appropriate alternatives based on your specific condition.

Q5: Can I still use this combination if I have an old bottle?

A: No. Using a banned medication is not recommended. Consult a physician for current treatment options.

Q6: What are the potential side effects of the individual components?

A: Naphazoline can cause rebound congestion, and chlorpheniramine can cause drowsiness. Other components may cause local irritation.

Q7: Are there any drug interactions I should be aware of regarding the individual components?

A: Yes. Naphazoline can interact with MAO inhibitors and some antidepressants. Chlorpheniramine can interact with other medications that cause drowsiness.

Q8: Is this combination safe during pregnancy?

A: The safety profile during pregnancy was not well established. Consult a doctor for appropriate alternatives during pregnancy.

Q9: What should I do if I experience side effects after using a similar eye drop?

A: Discontinue use and consult an ophthalmologist immediately.