Boric Acid + Chlorbutol + Chlorpheniramine Maleate + Hydroxypropylmethylcellulose + Naphazoline + Sodium Chloride + Zinc Sulfate

Usage

This combination is prescribed for the temporary relief of minor eye irritations, such as redness, discomfort, burning, and itching, often associated with allergies or exposure to irritants like pollen, dust, or smoke. It is also used to relieve dryness of the eye.

• Pharmacological Classification: This combination includes several classes of drugs:

  • Decongestant: Naphazoline
  • Antihistamine: Chlorpheniramine maleate
  • Lubricant: Hydroxypropylmethylcellulose
  • Astringent: Zinc sulfate
  • Antiseptic: Boric Acid and Chlorbutol

• Mechanism of Action: This ophthalmic solution works through multiple mechanisms:

  • Naphazoline constricts blood vessels in the eye, reducing redness.
  • Chlorpheniramine maleate blocks histamine receptors, relieving itching and allergic reactions.
  • Hydroxypropylmethylcellulose lubricates the eye surface, providing relief from dryness and irritation.
  • Zinc sulfate acts as an astringent.
  • Boric acid and Chlorbutol act as mild antiseptics.

Alternate Names

No specific alternate names exist for this precise combination of ingredients. However, it is often referred to as an “ophthalmic decongestant and antihistamine solution.” Several brand names are available, such as Zoline and Redif.

How It Works

• Pharmacodynamics: The combined effects of the ingredients provide symptomatic relief from eye irritation and redness. Naphazoline, as an alpha-adrenergic agonist, constricts conjunctival blood vessels, thereby reducing redness. Chlorpheniramine maleate, an H1 receptor antagonist, counteracts the effects of histamine, mitigating allergic symptoms like itching and watering. Hydroxypropylmethylcellulose, a lubricant, soothes the eye surface. Zinc sulfate acts as an astringent, while Boric Acid and Chlorbutol serve as mild antiseptics.
• Pharmacokinetics: Information on the pharmacokinetics of this specific combination is limited. However, ophthalmic administration primarily leads to local effects in the eye, with minimal systemic absorption.

Dosage

Standard Dosage

Adults:

Instill 1-2 drops in the affected eye(s) up to four times a day, or as directed by a physician.

Children:

Consult a pediatrician for appropriate dosing in children as product information available does not specify child dosage.

Special Cases:

Consult a physician for dosage adjustments in elderly patients and those with renal or hepatic impairment.

Clinical Use Cases

The available information primarily focuses on the use of this combination for minor eye irritations and does not specify dosing guidelines for intubation, surgical procedures, mechanical ventilation, ICU use, or emergency situations.

Side Effects

Common Side Effects

Burning or stinging upon instillation.

Rare but Serious Side Effects

Severe eye irritation, blurred vision, headache.

Contraindications

• Narrow-angle glaucoma
• Hypersensitivity to any of the components

Drug Interactions

• Monoamine oxidase inhibitors (MAOIs) may potentiate the pressor effect of naphazoline.

Pregnancy and Breastfeeding

Consult a physician before using during pregnancy or breastfeeding as the safety profile is not well established.

Drug Profile Summary

• Mechanism of Action: Decongestant, antihistamine, lubricant, antiseptic.
• Side Effects: Burning, stinging, blurred vision.
• Contraindications: Narrow-angle glaucoma, hypersensitivity.
• Drug Interactions: MAOIs
• Pregnancy & Breastfeeding: Consult a physician.
• Dosage: 1-2 drops up to four times daily, or as directed.

Popular Combinations

No specific popular combinations are documented for this exact formulation.

Precautions

• Avoid contact with soft contact lenses.
• If symptoms persist or worsen, consult a doctor.

FAQs (Frequently Asked Questions)

Q1: What is the recommended dosage for Boric Acid + Chlorbutol + Chlorpheniramine Maleate + Hydroxypropylmethylcellulose + Naphazoline + Sodium Chloride + Zinc Sulfate?

A: The typical dosage is 1-2 drops in the affected eye(s) up to four times a day. However, always follow the physician’s prescribed dosage.

Q2: Can this eye drop be used with contact lenses?

A: It is generally recommended to remove contact lenses before using this eye drop and wait at least 15 minutes before reinserting them.

Q3: What are the common side effects?

A: Common side effects include mild burning or stinging upon application.

Q4: Can pregnant or breastfeeding women use this eye drop?

A: Consult a physician before use during pregnancy or breastfeeding.

Q5: What should I do if I experience severe eye irritation after using this eye drop?

A: Discontinue use and consult a doctor immediately.

Q6: How long can I use this eye drop?

A: Use it only for the duration prescribed by the physician. Prolonged use of decongestants can lead to rebound congestion.

Q7: Can this combination be used for treating eye infections?

A: This combination is not intended to treat eye infections. Consult a physician for appropriate diagnosis and treatment.

Q8: Can I use this eye drop if I have glaucoma?

A: This combination is contraindicated in patients with narrow-angle glaucoma. Consult a physician before use if you have any type of glaucoma.

Q9: What if I accidentally ingest this eye drop?

A: Seek immediate medical attention or contact a poison control center.