Usage
This combination medication is primarily prescribed for nutritional deficiencies, particularly those related to bone and joint health, and nerve function. It is often used in conditions like osteoporosis, osteoarthritis, and as a nutritional supplement. It doesn’t fall neatly into a single pharmacological classification, but rather acts as a combined supplement addressing multiple deficiencies. The components work synergistically to improve bone density, support nerve health, and reduce inflammation.
Alternate Names
While there isn’t one single international nonproprietary name (INN) for this specific combination, the individual components are recognized by their respective INNs (e.g., calcitriol, cholecalciferol, cyanocobalamin). Brand names vary regionally; some examples include “Bio D3 Max” and “Techbone Max.” There might be new brand names available. More brand names may exist depending on the manufacturer and region.
How It Works
Pharmacodynamics:
- Calcitriol: The active form of Vitamin D, calcitriol, increases calcium absorption in the gut and regulates calcium and phosphate homeostasis, promoting bone mineralization.
- Calcium Carbonate: Provides a source of calcium, essential for bone health, muscle function, and nerve transmission.
- Omega-3 Fatty Acids (EPA and DHA): Exert anti-inflammatory effects, potentially beneficial in conditions like osteoarthritis. They also contribute to cardiovascular health.
- Methylcobalamin: A form of Vitamin B12, essential for nerve function, DNA synthesis, and red blood cell formation.
- Folic Acid: Another B vitamin (B9), crucial for cell growth and division, especially during periods of rapid growth like pregnancy. It plays a role in DNA synthesis and repair.
- Boron: While its exact mechanism is not fully understood, boron appears to influence calcium and vitamin D metabolism and may play a role in bone health.
Pharmacokinetics:
The individual components have different absorption, metabolism, and elimination profiles.
- Calcitriol is absorbed in the small intestine and hydroxylated in the liver and kidneys.
- Calcium carbonate absorption is influenced by vitamin D and dietary factors.
- Omega-3 fatty acids are absorbed in the intestines and incorporated into cell membranes.
- Methylcobalamin and folic acid are absorbed in the gastrointestinal tract.
- Boron absorption and excretion occur primarily through the kidneys.
Elimination pathways also vary: calcitriol and its metabolites are primarily excreted in bile, calcium is excreted through urine and feces, omega-3 fatty acids are metabolized like other fatty acids, methylcobalamin is excreted in bile and urine, folic acid is excreted primarily in urine, and boron is mainly excreted unchanged by the kidneys.
Dosage
The dosage of this combination product can vary depending on the specific formulation and the patient’s individual needs. It’s crucial to consult the specific product labeling and a healthcare professional for appropriate dosage recommendations.
Standard Dosage
A typical dosage may contain:
- Calcitriol: 0.25 mcg
- Omega-3 fatty acids: 300 mg (EPA 180mg + DHA 120 mg)
- Methylcobalamin: 1500 mcg
- Folic acid: 400 mcg
- Boron: 1.5 mg
- Calcium Carbonate: 500 mg
One capsule daily or as directed by the physician.
Adults: The standard adult dose will vary according to the specific product.
Children: Pediatric dosing should be determined by a pediatrician, considering age, weight, and specific nutritional needs.
Special Cases: Dosage adjustments may be necessary for elderly patients, those with renal or hepatic impairment, and individuals with comorbid conditions. A physician should carefully assess and adjust the dosage as needed.
Clinical Use Cases
This combination is not typically used in acute clinical settings like intubation, surgical procedures, mechanical ventilation, or the ICU. It’s primarily intended for long-term nutritional supplementation.
Dosage Adjustments Dosage adjustments are patient-specific and should be determined by a physician.
Side Effects
Common Side Effects
- Nausea
- Vomiting
- Constipation
- Diarrhea
- Headache
Rare but Serious Side Effects Hypercalcemia (high blood calcium levels)
Long-Term Effects Long-term excessive intake of certain components, like calcium or vitamin D, can have adverse effects.
Adverse Drug Reactions (ADR) ADRs are rare but can include hypersensitivity reactions.
Contraindications
- Hypercalcemia
- Vitamin D toxicity
- Hypersensitivity to any of the components
Drug Interactions
- Thiazide diuretics (may increase calcium levels)
- Some antibiotics (may affect calcium absorption)
- Medications affecting vitamin D metabolism
Pregnancy and Breastfeeding
This combination should be used during pregnancy and breastfeeding only if clearly needed and under the guidance of a physician.
Drug Profile Summary
- Mechanism of Action: Provides essential nutrients for bone health, nerve function, and overall well-being.
- Side Effects: Generally well-tolerated, but gastrointestinal issues and hypercalcemia can occur.
- Contraindications: Hypercalcemia, vitamin D toxicity.
- Drug Interactions: Thiazide diuretics, some antibiotics.
- Pregnancy & Breastfeeding: Consult a physician.
- Dosage: Varies; see product labeling and consult a physician.
- Monitoring Parameters: Calcium levels, vitamin D levels (if necessary).
Popular Combinations Often used as a standalone supplement.
Precautions Assess for pre-existing conditions and monitor for potential side effects.
FAQs (Frequently Asked Questions)
Q1: What is the recommended dosage for Boron + Calcitriol + Calcium Carbonate + Folic Acid + Methylcobalamin + Omega-3 fatty acid?
A: The dosage varies depending on the product and individual needs. Consult the product labeling and/or a physician.
Q2: Can this combination be used in children?
A: Pediatric use should be under the guidance of a pediatrician.
Q3: Are there any drug interactions I should be aware of?
A: Yes, potential interactions exist with thiazide diuretics and some antibiotics.
Q4: What are the common side effects?
A: Common side effects include nausea, vomiting, constipation, and headache.
Q5: Can this combination be used during pregnancy?
A: Consult a physician before use during pregnancy or breastfeeding.
Q6: What is the role of each component in this combination?
A: Each component contributes to different aspects of health: bone health (calcium, vitamin D, boron), nerve function (methylcobalamin, folic acid), and anti-inflammation (omega-3 fatty acids).
Q7: How should I take this medication?
A: Take as directed by your physician or as indicated on the product labeling. This medication usually comes in capsule form and is generally taken orally with water.
Q8: What should I do if I experience side effects?
A: If you experience any side effects, contact your healthcare provider immediately.
Q9: What is the best time to take this supplement?
A: It can be taken with or without food, but following a consistent time might be beneficial. Consult with your doctor for personalized guidance.
