Usage
This combination, found in products like Revici Injection, is used to control bleeding. It is primarily used as a haemostatic agent. It’s important to note that this specific combination product doesn’t have a widely recognized generic name or standardized usage guidelines. The provided sources do not list a specific pharmacological classification for this combined medication.
Alternate Names
There is no internationally recognized generic name for this specific drug combination. Butyl alcohol can exist as n-butanol, isobutanol, sec-butanol, and tert-butanol. Citric acid is also known as 2-hydroxy-1,2,3-propanetricarboxylic acid. Brand names include Revici Injection, Ableed Lotion.
How It Works
The exact mechanism of action for this combination is not fully understood. Some sources suggest it may work by increasing the strength of blood vessel walls and enhancing platelet aggregation.
Butyl alcohol may act as a solvent and potentially exhibits anesthetic or sedative properties. Citric acid acts as a pH adjuster. If sodium chloride is included, as in Revici Injection, it contributes to fluid balance. The pharmacokinetics and pharmacodynamics of this combination have not been extensively studied. Elimination pathways are not clearly defined.
Dosage
Dosage information is primarily available for Revici Injection. Consult the specific product’s prescribing information before use.
Standard Dosage
Adults:
Revici injection is administered as a 5ml intravenous injection by a healthcare professional.
Children:
The safety and efficacy have not been established in children.
Special Cases:
- Elderly Patients: Use with caution. Dosage adjustments may be necessary based on individual health conditions.
- Patients with Renal Impairment: Dosage adjustments should be based on patient-specific factors. Consult the product’s prescribing information.
- Patients with Hepatic Dysfunction: Dosage adjustments should be based on patient-specific factors. Consult the product’s prescribing information.
- Patients with Comorbid Conditions: Exercise caution in patients with cardiovascular conditions, liver, or kidney disease.
Clinical Use Cases
The sources focus on bleeding control but do not provide specific dosages for clinical situations like intubation, surgical procedures, mechanical ventilation, ICU use, or emergency situations. Consult specialized resources for guidance in these specific scenarios.
Dosage Adjustments
Dosage adjustments should be made based on patient-specific factors such as renal or hepatic dysfunction. Always consult the specific product’s prescribing information.
Side Effects
Common Side Effects
Nausea, diarrhea, headache. Local irritation at the injection site.
Rare but Serious Side Effects
Allergic reactions (swelling, itching, difficulty breathing, hives) require immediate medical attention.
Long-Term Effects
Limited data available on long-term effects.
Adverse Drug Reactions (ADR)
Allergic reactions are the most significant ADRs requiring immediate intervention.
Contraindications
Known hypersensitivity to any of the components. Use cautiously in patients with liver or kidney disease, cardiovascular conditions. Pregnancy and breastfeeding safety not established.
Drug Interactions
Limited information available. Due to the butyl alcohol component, caution is advised with medications metabolized by the liver. Refer to specific product information.
Pregnancy and Breastfeeding
Safety during pregnancy and breastfeeding has not been established. Avoid use unless the potential benefits outweigh the risks.
Drug Profile Summary
- Mechanism of Action: Not fully understood, possibly related to increased blood vessel wall strength and platelet aggregation.
- Side Effects: Nausea, diarrhea, headache, allergic reactions.
- Contraindications: Hypersensitivity, severe liver/kidney disease. Caution in pregnancy and breastfeeding.
- Drug Interactions: Limited information, potential with liver-metabolized drugs.
- Pregnancy & Breastfeeding: Not established; avoid use unless benefits outweigh risks.
- Dosage: 5ml intravenous injection by healthcare professional (for Revici Injection).
- Monitoring Parameters: Vital signs, signs of bleeding, allergic reactions.
Popular Combinations
No specific popular combinations are identified in mainstream medical practice for this mixture.
Precautions
- General Precautions: Administer intravenously by trained healthcare professional. Monitor for allergic reactions. Pre-screening for allergies and organ dysfunction is advisable.
- Specific Populations: Use cautiously in pregnant women, breastfeeding mothers, patients with liver/kidney disease, and the elderly.
- Lifestyle Considerations: Consult a doctor about alcohol consumption while on this medication.
FAQs (Frequently Asked Questions)
Q1: What is the recommended dosage for Butyl Alcohol + Citric Acid in Revici Injection?
A: 5ml intravenous injection by a healthcare professional.
Q2: Is this combination safe for children?
A: The safety and efficacy have not been established in children.
Q3: What are the common side effects?
A: Nausea, diarrhea, headache, and local irritation at the injection site.
Q4: Are there any serious side effects?
A: Allergic reactions can occur and require immediate medical attention.
Q5: Can this combination be used during pregnancy or breastfeeding?
A: Safety has not been established. Avoid use unless the potential benefits outweigh the risks.
Q6: How does this medication work?
A: The exact mechanism isn’t fully understood. It may involve increased blood vessel strength and enhanced platelet aggregation.
Q7: Are there any drug interactions I should be aware of?
A: Limited information is available. Caution is advised with drugs metabolized by the liver. Consult specific product information.
Q8: What should I do if a patient experiences an allergic reaction?
A: Stop the medication immediately and provide appropriate medical care for allergic reactions, which might include antihistamines or corticosteroids.
Q9: Are there any precautions for elderly patients?
A: Yes, use with caution in elderly patients and adjust the dose as needed based on their health condition.
