Usage
Revici Injection, a combination of butyl alcohol, citric acid, and sodium chloride, is primarily used to control and manage excessive bleeding. It is classified as a hemostatic agent. While the exact mechanism is not fully elucidated, it appears to strengthen blood vessel walls and improve platelet aggregation, thus promoting hemostasis and reducing re-bleeding episodes.
Alternate Names
This specific combination doesn’t have a widely recognized generic name or other alternate names. The product is commonly marketed under the brand name Revici Injection. Individually, citric acid is also known as 2-hydroxy-1,2,3-propanetricarboxylic acid. Butyl alcohol exists in several isomeric forms (n-butanol, isobutanol, sec-butanol, and tert-butanol).
How It Works
The pharmacodynamics of this combination are not fully understood. The components likely contribute synergistically. Butyl alcohol may act as a solvent and potentially exert anesthetic or sedative properties. Citric acid functions as a pH adjuster, ensuring optimal conditions for the other components. Sodium chloride maintains isotonicity with blood plasma, preventing cell lysis or shrinkage.
The pharmacokinetics of this combination have not been extensively studied. Information about absorption, metabolism, and elimination pathways for this specific mixture is limited. Butyl alcohol is primarily metabolized in the liver. Citric acid participates in the Krebs cycle. Sodium chloride is excreted renally.
Dosage
Standard Dosage
Adults:
Revici Injection is administered as a 5ml intravenous injection by a healthcare professional.
Children:
Safety and efficacy have not been established in children.
Special Cases:
- Elderly Patients: Use with caution; dose adjustments may be necessary depending on individual health conditions.
- Patients with Renal Impairment: Use with caution, and adjust the dosage based on the creatinine clearance rate.
- Patients with Hepatic Dysfunction: Exercise caution due to the potential impact on butyl alcohol metabolism.
- Patients with Comorbid Conditions: Assess the patient’s condition thoroughly and adjust the dosage as needed, especially with cardiovascular disease.
Clinical Use Cases
The sources provided primarily describe the use of Revici Injection in controlling bleeding. Specific dosage recommendations for clinical situations like intubation, surgical procedures, mechanical ventilation, ICU use, and emergency situations (e.g., cardiac arrest) are not detailed in the sources.
Dosage Adjustments
Dose modification should be considered in patients with hepatic or renal impairment. No information is available regarding the influence of metabolic disorders or genetic polymorphisms on drug metabolism.
Side Effects
Common Side Effects
Rare but Serious Side Effects
- Allergic reactions (rash, itching, difficulty breathing, swelling).
Long-Term Effects
No data are available on the long-term effects of Revici Injection.
Adverse Drug Reactions (ADR)
Severe allergic reactions such as anaphylaxis and angioedema.
Contraindications
- Hypersensitivity to any of the components.
- Severe liver or kidney disease.
Drug Interactions
Limited information is available. Caution is advised with medications metabolized by the liver due to the butyl alcohol component. Avoid alcohol consumption after taking this medicine.
Pregnancy and Breastfeeding
Safety during pregnancy and breastfeeding has not been established. Avoid use unless the potential benefits outweigh the risks.
Drug Profile Summary
- Mechanism of Action: Potentially increases blood vessel wall strength and platelet aggregation. Not fully understood.
- Side Effects: Nausea, diarrhea, headache, allergic reactions.
- Contraindications: Hypersensitivity, severe liver/kidney disease.
- Drug Interactions: Limited information, potential interactions with liver-metabolized drugs.
- Pregnancy & Breastfeeding: Not established; avoid use unless benefits outweigh risks.
- Dosage: 5ml intravenous injection.
- Monitoring Parameters: Vital signs, bleeding signs, allergic reactions.
Popular Combinations
No specific popular combinations exist for this mixture.
Precautions
- General Precautions: Pre-screening for allergies, liver/kidney disease, cardiovascular conditions.
- Specific Populations: Use cautiously in pregnant women, breastfeeding mothers, children, and the elderly.
- Lifestyle Considerations: Avoid alcohol consumption.
FAQs (Frequently Asked Questions)
Q1: What is the recommended dosage for Butyl Alcohol + Citric Acid + Sodium Chloride (Revici Injection)?
A: 5ml intravenous injection administered by a healthcare professional.
Q2: How does Revici Injection work to control bleeding?
A: It appears to strengthen blood vessel walls and improve platelet aggregation. The precise mechanism is not completely understood.
Q3: Can Revici Injection be used in children?
A: Safety and efficacy have not been established in children.
Q4: Are there any contraindications for using Revici Injection?
A: Yes, hypersensitivity to any component and severe liver or kidney disease are contraindications.
Q5: What are the common side effects of Revici Injection?
A: Nausea, diarrhea, and headache are common side effects.
Q6: Can pregnant or breastfeeding women use Revici Injection?
A: Safety during pregnancy and breastfeeding has not been established. Use only if benefits clearly outweigh risks.
Q7: Are there any drug interactions to be aware of with Revici Injection?
A: Limited information is available. Caution is advised with drugs metabolized by the liver. Avoid alcohol.
Q8: How should Revici Injection be administered?
A: It should be administered as a 5ml intravenous injection only by a trained healthcare professional.
Q9: What are the monitoring parameters for patients receiving Revici Injection?
A: Monitor vital signs, signs of bleeding, and for potential allergic reactions.
