Usage
This combination of Calcitriol, Calcium Carbonate, L-Methyl Folate, Magnesium, Methylcobalamin, Vitamin K2-7, and Zinc is primarily used as a dietary supplement to support bone health, nerve function, and overall well-being. It is often prescribed for conditions like osteoporosis, osteomalacia, and vitamin deficiencies. It doesn’t fit neatly into a single pharmacological classification but can be considered a nutritional supplement with components having effects relating to bone metabolism, vitamin supplementation, and nerve health. The components work synergistically to improve calcium absorption, bone mineralization, and nerve function.
Alternate Names
This combination medication does not have a universally recognized international nonproprietary name (INN). It is often referred to by the names of its components or by brand names specific to manufacturers. Some brand names include “CALCIQ – K2 7 PLUS”, “BETERCAL K2 7”, and “Swascal K2-7 Plus”.
How It Works
Pharmacodynamics: This combination product affects the body by supplementing essential nutrients involved in various physiological processes. Calcium and Vitamin D (Calcitriol) are crucial for bone health. Vitamin K2-7 directs calcium to the bones, preventing its deposition in soft tissues. Methylcobalamin (Vitamin B12) and L-Methyl Folate are vital for nerve function and DNA synthesis. Magnesium supports muscle and nerve function, while Zinc plays a role in immune function and cell growth.
Pharmacokinetics: Calcium carbonate is absorbed in the small intestine, enhanced by calcitriol. Calcitriol itself undergoes hepatic metabolism. Vitamin K2-7 is absorbed and transported with lipids. Methylcobalamin is absorbed and stored in the liver. L-Methyl folate is readily absorbed. Magnesium absorption varies depending on dietary intake. Zinc is absorbed in the small intestine. Elimination pathways vary for each component, but primarily involve renal and hepatic excretion.
Dosage
Standard Dosage
Adults:
The typical adult dosage is one capsule per day, taken orally with a meal. Some sources recommend twice daily administration.
Children:
Pediatric dosing should be determined by a pediatrician based on the child’s age, weight, and specific needs.
Special Cases:
Dosage adjustments are necessary for patients with renal or hepatic impairment. Consult with a nephrologist or hepatologist, respectively, for appropriate dose modifications. Dosage adjustments in the elderly and patients with comorbid conditions should be individualized based on their specific needs and health status.
Clinical Use Cases
This combination is not typically used in acute clinical settings like intubation, surgical procedures, mechanical ventilation, ICU use, or emergency situations.
Dosage Adjustments
Dose modification should be considered in patients with renal or hepatic dysfunction, as well as those with certain metabolic disorders.
Side Effects
Common Side Effects
Constipation, nausea, and gastrointestinal upset.
Rare but Serious Side Effects
Hypercalcemia (high blood calcium levels), allergic reactions.
Long-Term Effects
Kidney stones with prolonged excessive intake of calcium.
Adverse Drug Reactions (ADR)
Rare but serious ADRs may include severe allergic reactions.
Contraindications
Hypercalcemia, hypersensitivity to any component, severe renal impairment.
Drug Interactions
This combination may interact with certain medications, such as bisphosphonates, antibiotics (tetracyclines, quinolones), and thyroid hormones. Consult a healthcare professional before co-administering with other drugs.
Pregnancy and Breastfeeding
Consult with a healthcare professional before use during pregnancy or breastfeeding.
Drug Profile Summary
Mechanism of Action: Improves calcium absorption, bone mineralization, and nerve function.
Side Effects: Constipation, nausea, gastrointestinal upset, hypercalcemia (rare).
Contraindications: Hypercalcemia, hypersensitivity, severe renal impairment.
Drug Interactions: Bisphosphonates, antibiotics (tetracyclines, quinolones), thyroid hormones.
Pregnancy & Breastfeeding: Consult a healthcare professional.
Dosage: Typically one capsule daily for adults.
Monitoring Parameters: Serum calcium, vitamin D, and B12 levels.
Popular Combinations
Often used alone as a comprehensive supplement.
Precautions
Assess for pre-existing conditions, monitor for side effects. Caution advised in pregnancy and breastfeeding. Consult a healthcare professional before use.
FAQs (Frequently Asked Questions)
Q1: What is the recommended dosage for this combination?
A: One capsule daily for adults, preferably with a meal. Pediatric and special population dosages should be individualized based on need and clinical assessment.
Q2: What are the common side effects?
A: Constipation, nausea, and gastrointestinal discomfort.
Q3: Who should not take this combination?
A: Individuals with hypercalcemia, hypersensitivity to any component, or severe renal impairment.
Q4: Can pregnant or breastfeeding women take this supplement?
A: Consult a healthcare professional before use.
Q5: Are there any drug interactions I should be aware of?
A: Yes, potential interactions exist with certain medications like bisphosphonates, some antibiotics, and thyroid hormones.
Q6: What is the role of each component in this combination?
A: Calcitriol and calcium support bone health, vitamin K2-7 directs calcium to bones, methylcobalamin and L-methyl folate support nerve function, magnesium supports muscle and nerve function, and zinc aids immune function and cell growth.
Q7: How should this medication be taken?
A: Orally, with a meal. The frequency may vary based on individual needs and should be decided by a healthcare provider.
Q8: What should I do if I miss a dose?
A: Take the missed dose as soon as you remember. If it is near the time of the next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose to catch up.
Q9: How long does it take to see the benefits of this supplement?
A: The onset of benefits can vary depending on individual factors and the specific health condition being addressed. It is essential to take the supplement consistently as directed by a healthcare professional and to maintain regular follow-up appointments to monitor progress.
