Usage
This combination medication is primarily prescribed for conditions related to vitamin and mineral deficiencies, particularly those affecting bone health, nerve function, and overall well-being. It may be used in conditions such as osteoporosis, osteomalacia, and rickets. It may also be prescribed to support overall health, particularly nerve function, red blood cell production, and immune system modulation. This is not a single pharmacological class drug, but rather a combination of supplements, vitamins, and minerals, each belonging to different classifications.
Alternate Names
This combination medication does not have a universally recognized international nonproprietary name (INN). It is often referred to by the names of its individual components. Brand names vary regionally; examples include Lycorixx-Ultra, Build-D3 Max, and Citmoss Forte.
How It Works
Pharmacodynamics: This combination product exerts its effects through the combined actions of its individual components.
- Calcitriol: The active form of vitamin D, calcitriol regulates calcium and phosphate absorption, promoting bone mineralization.
- Calcium Citrate Malate: Provides calcium, essential for bone health, muscle function, and nerve transmission. This form of calcium is highly bioavailable.
- L-Methyl Folate: The active form of folic acid, essential for DNA synthesis, cell division, and red blood cell formation.
- Lycopene: An antioxidant that protects cells from damage caused by free radicals.
- Magnesium Sulphate: Magnesium is crucial for various bodily functions, including muscle and nerve function, blood pressure regulation, and blood glucose control.
- Methylcobalamin: The active form of vitamin B12, vital for nerve function, DNA synthesis, and red blood cell formation.
- Omega-3 Fatty Acids: These essential fatty acids have anti-inflammatory properties and support cardiovascular health.
- Pyridoxal-5-Phosphate: The active form of Vitamin B6, it plays a role in brain development and function and the synthesis of neurotransmitters.
Pharmacokinetics: The absorption, metabolism, and elimination of each component vary:
- Calcitriol: Absorbed in the small intestine, metabolized in the liver and kidneys.
- Calcium Citrate Malate: Absorbed in the small intestine, influenced by vitamin D levels.
- L-Methyl Folate: Absorbed in the small intestine.
- Lycopene: Absorbed better with dietary fats, metabolized in the liver.
- Magnesium Sulphate: Absorbed in the small intestine, excreted renally.
- Methylcobalamin: Absorbed in the small intestine, stored in the liver.
- Omega-3 Fatty Acids: Absorbed in the small intestine, incorporated into cell membranes.
- Pyridoxal-5-Phosphate: Absorbed in the small intestine.
Dosage
Dosage needs to be individualized based on the patient’s specific requirements and underlying conditions. Always consult a healthcare professional for personalized dosage recommendations.
Standard Dosage
Adults:
Dosage varies depending on the specific formulation and clinical indication. A healthcare professional should determine the appropriate dose.
Children:
Pediatric dosing should be determined by a healthcare professional based on age, weight, and clinical condition.
Special Cases:
Dosage adjustments should be made for patients with renal or hepatic impairment, as well as those with comorbid conditions. This should be determined by a physician.
Clinical Use Cases
The use of this combination in specific clinical settings like intubation, surgical procedures, mechanical ventilation, or the ICU should be under the guidance of a physician. There is no established dosage regimen for these scenarios.
Dosage Adjustments
Dose modifications are necessary based on patient-specific factors, including renal/hepatic dysfunction, metabolic disorders, or genetic polymorphisms.
Side Effects
Common Side Effects
Gastrointestinal issues (constipation, nausea, vomiting, diarrhea), allergic reactions, headaches, digestive discomfort are possible.
Rare but Serious Side Effects
Hypercalcemia (elevated blood calcium levels) can occur with excessive calcium or vitamin D intake.
Long-Term Effects
Long-term excessive intake of certain vitamins or minerals can lead to potential health issues.
Adverse Drug Reactions (ADR)
Serious adverse drug reactions are rare but possible with any component of the medication.
Contraindications
Contraindications include hypersensitivity to any component of the combination, hypercalcemia, hypervitaminosis D, and severe renal impairment.
Drug Interactions
Potential interactions can occur with certain medications, including antacids, antibiotics, and diuretics. Consult a healthcare professional regarding specific interactions.
Pregnancy and Breastfeeding
This medication should be used during pregnancy and breastfeeding only if clearly needed and under the supervision of a healthcare professional.
Drug Profile Summary
- Mechanism of Action: See “How It Works” section.
- Side Effects: Gastrointestinal issues, allergic reactions, headaches, potential for hypercalcemia.
- Contraindications: Hypersensitivity, hypercalcemia, hypervitaminosis D, severe renal impairment.
- Drug Interactions: Antacids, antibiotics, diuretics.
- Pregnancy & Breastfeeding: Consult a healthcare professional.
- Dosage: Determined by a healthcare professional.
- Monitoring Parameters: Calcium levels, vitamin D levels.
Popular Combinations
This combination itself represents a common grouping of nutrients often prescribed together. Other combinations might include specific medications depending on the individual’s health needs.
Precautions
Standard precautions include assessment for allergies, metabolic disorders, and organ dysfunction. Specific precautions should be taken in pregnant/breastfeeding women, children, and the elderly.
FAQs (Frequently Asked Questions)
Q1: What is the recommended dosage for this combination?
A: The dosage needs to be individualized. Consult with a healthcare professional for recommendations.
Q2: Can this combination be taken during pregnancy?
A: Only if clearly needed and under the supervision of a healthcare professional.
Q3: What are the common side effects?
A: Gastrointestinal issues, allergic reactions, and headaches are possible.
Q4: Are there any drug interactions I should be aware of?
A: Yes, potential interactions exist with certain medications. Consult a healthcare professional.
Q5: What is the role of each component in this combination?
A: Each component contributes to overall health, particularly bone health, nerve function, red blood cell production, and immune support.
Q6: How should this medication be stored?
A: Store in a cool, dry place away from direct sunlight and out of reach of children.
Q7: Can this combination be used in children?
A: Yes, but pediatric dosing should be determined by a healthcare professional.
Q8: What should I do if I experience side effects?
A: Contact your healthcare professional if you experience any bothersome or persistent side effects.
Q9: Is this combination safe for long-term use?
A: Generally safe, but long-term use should be monitored by a healthcare professional.
