Usage
This combination medication is primarily prescribed for nutritional deficiencies, especially concerning calcium, vitamin D, vitamin B12, and folate. It supplements these essential nutrients when dietary intake is inadequate. It’s also used to support bone health, nerve function, and overall metabolic processes. It’s difficult to classify this combination under a single pharmacological category due to its diverse components. It can be considered a nutritional supplement with multiple actions.
Alternate Names
This combination medication lacks a universally recognized international nonproprietary name (INN). It’s marketed under various brand names, including Calchole Max, Rosacal-Max, and Amzy K2 7, among others. Specific names may vary regionally.
How It Works
This combination medication works through the synergistic action of its components:
- Coral calcium: Provides calcium and magnesium, essential for bone health, muscle function, and nerve transmission.
- Calcitriol: The active form of vitamin D, enhances calcium absorption and bone mineralization.
- Methylcobalamin: A form of vitamin B12, crucial for nerve function, DNA synthesis, and red blood cell formation.
- Omega-3 fatty acids: Have anti-inflammatory properties and support cardiovascular health.
- Vitamin K2-7: Directs calcium to bones, preventing its deposition in arteries.
- Zinc Sulphate Monohydrate: Supports immune function, wound healing, and cell growth.
- L-Methyl Folate: The active form of folic acid, essential for cell division and growth, especially during pregnancy.
- Lycopene: An antioxidant that may protect against certain cancers and cardiovascular diseases.
- Pyridoxal-5-phosphate: The active form of vitamin B6, plays a role in various metabolic processes.
The pharmacokinetics of each component influences absorption, distribution, metabolism, and elimination. For instance, calcitriol is metabolized in the liver and kidneys, while methylcobalamin is stored in the liver. Elimination pathways vary depending on the specific component. Specific details on receptor binding, enzyme inhibition, or neurotransmitter modulation would depend on individual components of this multi-ingredient formulation.
Dosage
Dosage guidelines vary based on the brand and individual patient needs. Consulting a physician for personalized dosing recommendations is crucial. The following provides general guidance:
Standard Dosage
Adults:
A typical dosage might be one softgel capsule daily, preferably with a meal. Some brands may recommend twice-daily administration. A physician should determine the maximum daily dose.
Children:
Pediatric dosing should be determined by a physician based on the child’s weight, age, and specific needs.
Special Cases:
- Elderly Patients: Dose adjustments may be necessary based on renal function and overall health.
- Patients with Renal Impairment: Dose reduction may be required depending on the degree of impairment.
- Patients with Hepatic Dysfunction: Dosage modifications may be needed due to altered metabolism.
- Patients with Comorbid Conditions: Dosage should be individualized considering other medical conditions.
Clinical Use Cases
Specific dosage recommendations for clinical settings like intubation, surgical procedures, mechanical ventilation, ICU use, or emergency situations should be determined by the attending physician based on the individual patient’s condition.
Dosage Adjustments
Dose modifications are based on patient-specific factors, including renal/hepatic dysfunction, metabolic disorders, or genetic polymorphisms affecting drug metabolism, and should be guided by a healthcare professional.
Side Effects
Common Side Effects
Limited data is available on the specific side effects of this combination. Individual components may cause gastrointestinal upset, such as nausea, constipation, or diarrhea.
Rare but Serious Side Effects
Allergic reactions, hypercalcemia (with excessive calcium intake), or other adverse effects related to individual components are possible.
Long-Term Effects
Long-term effects are not well established for this combination. Monitoring for potential complications related to individual components is advisable.
Adverse Drug Reactions (ADR)
Clinically significant ADRs associated with any component require immediate medical attention.
Contraindications
Contraindications may include hypersensitivity to any component, hypercalcemia, or conditions where specific components are contraindicated (e.g., severe renal impairment for calcitriol).
Drug Interactions
Potential drug interactions include interactions between the various components and with other medications. For example, vitamin K2-7 can interact with anticoagulants. Interactions with commonly prescribed medications, OTC drugs, supplements, and lifestyle factors (alcohol, smoking, grapefruit juice) warrant consideration. Specific CYP450 interactions should be evaluated based on individual components.
Pregnancy and Breastfeeding
The safety of this combination during pregnancy and breastfeeding hasn’t been fully established. Consulting a physician is essential before using this combination during these periods.
Drug Profile Summary
- Mechanism of Action: Synergistic action of vitamins, minerals, and antioxidants to address nutritional deficiencies and support bone health, nerve function, and metabolic processes.
- Side Effects: Limited data; potential for gastrointestinal upset and component-specific side effects.
- Contraindications: Hypersensitivity, hypercalcemia, and component-specific contraindications.
- Drug Interactions: Potential interactions with anticoagulants and other medications.
- Pregnancy & Breastfeeding: Consult a physician before use.
- Dosage: Varies based on individual needs; typically one softgel capsule daily for adults.
- Monitoring Parameters: Monitor calcium levels, renal function, and other relevant parameters based on individual components.
Popular Combinations
Data on popular combinations specific to this multi-ingredient formulation isn’t readily available. Clinicians often tailor combinations of vitamins and minerals based on individual patient needs.
Precautions
- General Precautions: Assess for allergies, metabolic disorders, and organ dysfunction.
- Specific Populations: Exercise caution in pregnant/breastfeeding women, children, and the elderly.
- Lifestyle Considerations: Evaluate alcohol, smoking, and dietary habits.
FAQs (Frequently Asked Questions)
Q1: What is the recommended dosage for this combination?
A: Standard adult dosage is typically one softgel daily, but it’s crucial to consult a physician for personalized recommendations considering individual patient factors.
Q2: Can this combination be used during pregnancy?
A: Safety during pregnancy isn’t fully established. Consult a physician before use.
Q3: What are the common side effects?
A: While data is limited, some individuals might experience gastrointestinal upset.
Q4: Does this combination interact with other medications?
A: Yes, potential interactions exist, particularly with anticoagulants and certain other medications. A detailed medication review with a physician is recommended.
Q5: Can this combination be used in children?
A: Pediatric use should be determined and monitored by a physician.
Q6: What should be monitored while taking this combination?
A: Monitoring parameters include calcium levels, renal function, and other relevant markers based on individual components. Regular medical check-ups are advised.
Q7: What is the role of Vitamin K2-7 in this combination?
A: Vitamin K2-7 helps direct calcium to the bones, reducing the risk of calcium deposits in arteries.
Q8: What are the benefits of L-Methyl Folate?
A: L-Methyl Folate, the active form of folic acid, is crucial for cell division and growth, particularly important during pregnancy for preventing neural tube defects.
A: Omega-3 fatty acids have anti-inflammatory properties and support cardiovascular health.
