Usage
Carboxymethylcellulose + Oxychloro Complex is prescribed for the relief of dry eye symptoms, such as burning, stinging, irritation, and discomfort. It is also used to protect the eyes from further irritation or dryness caused by environmental factors like wind, sun, or prolonged computer use. It is classified as an ophthalmic lubricant and preservative. The mechanism of action involves carboxymethylcellulose lubricating the ocular surface, mimicking the mucin layer of tears, and oxychloro complex acting as a preservative.
Alternate Names
This combination is often referred to as artificial tears. Some products containing this combination may use brand names like “Carbosol”, “Add Tears”, “Refresh Tears”, “Locfresh”, “Relub LC”, “FloGel”, “ForLube”, “New Softdrops 0.5”, “Eqifresh Gel,” among others.
How It Works
Pharmacodynamics: Carboxymethylcellulose increases tear film viscosity and prolongs tear film break-up time, moisturizing and protecting the ocular surface. Oxychloro complex acts as a preservative, preventing bacterial growth in multi-dose eye drops.
Pharmacokinetics: Carboxymethylcellulose, applied topically as eye drops, exhibits negligible systemic absorption. Oxychloro complex, as a preservative in eye drops, also demonstrates minimal systemic absorption. Therefore, data on metabolism and elimination are limited.
Mode of Action: Carboxymethylcellulose, a cellulose derivative, functions as a lubricant, adhering to the eye’s surface and mimicking the mucin layer of natural tears. It creates a protective shield, hydrating and lubricating the cornea. Oxychloro complex acts as a broad-spectrum antimicrobial agent, preventing bacterial and fungal contamination in the eye drop solution.
Receptor Binding/Enzyme Inhibition/Neurotransmitter Modulation: Carboxymethylcellulose and oxychloro complex do not exhibit receptor binding, enzyme inhibition, or neurotransmitter modulation activities. Their primary functions are lubrication and preservation, respectively.
Dosage
Standard Dosage
Adults: Instill 1-2 drops in the affected eye(s) as needed, typically 4 times a day, or up to 8 times a day for severe dryness.
Special Cases:
- Elderly Patients: No specific dosage adjustments are usually necessary.
- Patients with Renal Impairment: No dose adjustments are needed.
- Patients with Hepatic Dysfunction: No dose adjustments are needed.
- Patients with Comorbid Conditions: Use with caution in patients with severe allergies or hypersensitivity to eye products. Consult with a doctor for pre-existing severe eye conditions.
Clinical Use Cases
The standard dosage (1-2 drops as needed) applies to various clinical settings, including:
- Intubation: Use as needed to maintain ocular moisture.
- Surgical Procedures: Use as needed before, during, or after procedures to protect the cornea.
- Mechanical Ventilation: Use as needed to prevent corneal drying.
- Intensive Care Unit (ICU) Use: Use regularly to maintain ocular moisture.
- Emergency Situations: Use as needed for ocular lubrication.
Dosage Adjustments
No specific dosage adjustments are indicated based on renal/hepatic function, metabolic disorders, or genetic polymorphisms.
Side Effects
Common Side Effects
- Temporary blurred vision
- Mild stinging or burning upon instillation
- Eye irritation (including burning and discomfort)
- Watery eyes
- Eye redness
Rare but Serious Side Effects
- Allergic reactions (eyelid swelling, itching)
- Worsening of dry eye symptoms
- Eye pain
- Changes in vision
Long-Term Effects
No specific long-term adverse effects have been reported with carboxymethylcellulose and oxychloro complex eye drops. However, it is essential to monitor patients for any unusual ocular symptoms during prolonged use.
Adverse Drug Reactions (ADR)
Clinically significant ADRs are rare. Any persistent or severe eye pain, vision changes, or allergic reaction warrants immediate medical attention.
Contraindications
- Known hypersensitivity to any of the ingredients.
Drug Interactions
- While no specific drug interactions have been documented, advise patients to wait 15 minutes after using other eye drops before instilling this product.
Pregnancy and Breastfeeding
Due to negligible systemic exposure, this combination is generally considered safe during pregnancy and breastfeeding. However, always consult a healthcare professional before use.
Drug Profile Summary
- Mechanism of Action: Carboxymethylcellulose lubricates, oxychloro complex preserves.
- Side Effects: Blurred vision, stinging, irritation, redness.
- Contraindications: Hypersensitivity to any ingredient.
- Drug Interactions: Potential interaction with other eye drops, maintain a 15-minute interval.
- Pregnancy & Breastfeeding: Generally safe, consult a doctor.
- Dosage: 1-2 drops as needed, up to 8 times/day.
- Monitoring Parameters: Observe for any signs of eye irritation, pain, vision changes, or allergic reactions.
Popular Combinations
Carboxymethylcellulose is often combined with other lubricants, such as glycerin, or with other ocular medications addressing specific conditions.
Precautions
- General Precautions: Avoid contamination; do not touch the bottle tip to any surface. Wash hands before use. If the solution changes color or becomes cloudy, discard it. If symptoms worsen or persist beyond 72 hours, consult a doctor.
- Specific Populations: No specific precautions for pregnant/breastfeeding women, children, or the elderly beyond standard recommendations.
- Lifestyle Considerations: No specific lifestyle considerations. Transient blurred vision after instillation may temporarily affect driving or operating machinery.
FAQs (Frequently Asked Questions)
Q1: What is the recommended dosage for Carboxymethylcellulose + Oxychloro Complex?
A: The usual dose is 1-2 drops in the affected eye(s) as needed, up to 4 times daily, or as directed by the physician. For severe dry eye, up to 8 times/day might be necessary.
A: While some formulations are compatible with contact lenses, it is generally advisable to remove lenses before instilling the drops and wait 15 minutes before reinserting them.
Q3: What should I do if I experience blurred vision after using the drops?
A: Transient blurred vision is common. Wait until your vision clears before driving or operating machinery. If blurring persists or is severe, consult your doctor.
Q4: Are there any known drug interactions with Carboxymethylcellulose + Oxychloro Complex?
A: No specific drug interactions have been documented. However, it’s prudent to wait at least 15 minutes after using other eye drops before using this product.
Q5: Can pregnant or breastfeeding women use this product?
A: Due to minimal systemic absorption, it is generally considered safe during pregnancy and breastfeeding. However, always consult with a healthcare professional before using any medication during these periods.
Q6: What are the signs of an allergic reaction to the eye drops?
A: Signs of an allergic reaction can include itching, redness, swelling of the eyelids, or a feeling of something in the eye. Discontinue use and seek medical attention if these symptoms occur.
Q7: How should I store the eye drops?
A: Store at room temperature (15-30°C) away from direct sunlight and excessive heat. Discard any unused solution after the expiry date or one month after opening the bottle.
Q8: Is it safe to use Carboxymethylcellulose + Oxychloro Complex long-term?
A: Long-term use is generally safe. However, regular check-ups with an ophthalmologist are recommended to monitor eye health and adjust treatment as needed.
Q9: What are the alternative treatments for dry eyes if this product doesn’t work?
A: Other options for dry eye treatment include other artificial tears, ointments, punctal plugs, or prescription medications such as cyclosporine ophthalmic emulsion. Your doctor can help determine the most appropriate treatment based on your individual needs.
