Usage
Choline salicylate + tannic acid is primarily used for the topical treatment of mild to moderate pain and inflammation in the mouth and gums, particularly associated with gingivitis, stomatitis, and mouth ulcers. It belongs to the pharmacological classes of analgesics, anti-inflammatory agents, and astringents.
The mechanism of action involves the following: Choline salicylate, a non-steroidal anti-inflammatory drug (NSAID), inhibits prostaglandin synthesis, reducing pain and inflammation. Tannic acid acts as an astringent, causing constriction of tissues and reducing bleeding.
Alternate Names
This combination doesn’t have a universally recognized international nonproprietary name (INN). Regional or international variations may exist. Brand names include Dent Glow Gum Paint and T-32 Gum Paint. Stomela Jel was a brand that contained this combination along with other ingredients.
How It Works
Pharmacodynamics: Choline salicylate exerts its analgesic and anti-inflammatory effects by inhibiting cyclooxygenase (COX) enzymes, particularly COX-1 and COX-2. This action reduces the production of prostaglandins, key mediators of pain and inflammation. Tannic acid precipitates proteins, creating a protective layer over the affected area. This astringent effect helps to reduce bleeding, soothe irritation, and promote tissue healing.
Pharmacokinetics: Choline salicylate is absorbed through the oral mucosa. Information regarding its specific metabolism and elimination when used topically is limited. Tannic acid is not readily absorbed through the oral mucosa, and its primary action is local.
Mode of Action: Choline salicylate’s mode of action involves non-selective COX inhibition, decreasing prostaglandin synthesis. Tannic acid’s mode of action is based on its astringent properties, precipitating proteins to form a protective film and constrict tissues.
Receptor Binding, Enzyme Inhibition, or Neurotransmitter Modulation: The primary action of choline salicylate involves the inhibition of COX enzymes. Tannic acid does not directly interact with receptors or modulate neurotransmitters but exerts its effect through protein precipitation and tissue constriction.
Elimination Pathways: Information regarding elimination pathways when used topically in this combination is limited. Systemically administered salicylates are primarily metabolized in the liver and excreted by the kidneys.
Dosage
Standard Dosage
Adults: Apply a small amount of the gel or paint to the affected area 2-3 times daily, preferably after meals and before bedtime. Use a clean cotton swab or fingertip for application.
Children (6 years and older): Apply a smaller amount once or twice daily under adult supervision.
Special Cases:
Limited information is available on dosage modifications for special populations like the elderly or patients with renal/hepatic impairment when used topically. Consult a healthcare professional for guidance.
Clinical Use Cases
The provided sources do not list dosage recommendations for settings like intubation, surgical procedures, mechanical ventilation, ICU use, or emergency situations. This combination is primarily for topical oral use.
Dosage Adjustments
Dosage adjustments may be necessary in special populations, as advised by a physician.
Side Effects
Common Side Effects:
Mild irritation or a stinging sensation at the application site is possible.
Rare but Serious Side Effects:
Allergic reactions, including swelling, redness, itching, or difficulty breathing, can occur. Seek immediate medical attention if these appear.
Long-Term Effects:
No information is available regarding long-term systemic effects with topical application.
Adverse Drug Reactions (ADR):
Severe allergic reactions are the most significant potential ADRs, requiring prompt medical intervention.
Contraindications
Contraindications include hypersensitivity to salicylates, tannic acid, or any component of the formulation.
Drug Interactions
Clinically significant drug interactions with topical choline salicylate + tannic acid are unlikely. However, inform your physician about all other medications you are taking.
Pregnancy and Breastfeeding
Limited data is available on the safety of this combination during pregnancy and breastfeeding. Consult your doctor before using it if you are pregnant, planning to become pregnant, or are breastfeeding.
Drug Profile Summary
- Mechanism of Action: Choline salicylate: COX inhibitor, reducing prostaglandin synthesis. Tannic acid: Astringent, constricting tissues and creating a protective layer.
- Side Effects: Mild irritation, allergic reactions.
- Contraindications: Hypersensitivity to components.
- Drug Interactions: Limited information available.
- Pregnancy & Breastfeeding: Consult a physician before use.
- Dosage: Adults: Apply a small amount 2-3 times/day; Children (6+ years): Apply a smaller amount 1-2 times/day.
- Monitoring Parameters: Observe for local irritation or allergic reactions.
Popular Combinations
The combination of choline salicylate, tannic acid, cetrimide, and lignocaine is marketed as an oral gel or paint.
Precautions
- General Precautions: Assess for allergies to components before use.
- Specific Populations: Consult a physician for use during pregnancy and breastfeeding. Supervise use in children. Limited data for dose adjustments in elderly patients or those with hepatic/renal impairment.
FAQs (Frequently Asked Questions)
Q1: What is the recommended dosage for Choline Salicylate + Tannic Acid?
A: Adults: Apply a small amount to the affected area 2-3 times/day. Children (6+): Apply a smaller amount 1-2 times/day.
Q2: How does Choline Salicylate + Tannic Acid work?
A: Choline salicylate reduces pain and inflammation, while tannic acid acts as an astringent.
Q3: What are the potential side effects?
A: Common side effects include mild irritation. Rare but serious effects include allergic reactions.
Q4: Can I use this product if I am pregnant or breastfeeding?
A: Consult your physician before using it during pregnancy or breastfeeding.
Q5: Are there any drug interactions I should be aware of?
A: Clinically significant drug interactions with topical use are unlikely. Inform your physician about all medications you are taking.
Q6: How long should I use this product?
A: Use as directed by your physician or as per package instructions.
Q7: What should I do if I experience an allergic reaction?
A: Discontinue use immediately and seek medical attention.
Q8: Can I use this product for other types of pain?
A: This product is specifically for topical use in the mouth and gums. Consult a physician for other types of pain.
Q9: Is it safe to swallow Choline Salicylate + Tannic Acid oral gel/paint?
A: It is meant for topical application only. Avoid swallowing the product. If accidental ingestion occurs, contact a poison control center or seek medical advice.
