Usage
This combination of ingredients is primarily used as a nutritional supplement to support overall health and address specific deficiencies. It is often prescribed for male infertility, asthenozoospermia (reduced sperm motility), and oligospermia (low sperm count). It is not classified as a drug, but rather a nutritional supplement and therefore doesn’t have a specific pharmacological classification. The components work synergistically to support various bodily functions related to energy production, antioxidant protection, and sperm health.
Alternate Names
This combination does not have a universally recognized international nonproprietary name (INN). It is typically identified by its component ingredients. Brand names may vary regionally; Maxoza is one example.
How It Works
Pharmacodynamics: The components of this supplement exert their effects through various mechanisms:
- Coenzyme Q10: Acts as an antioxidant and participates in mitochondrial electron transport chain, crucial for cellular energy production.
- Levo-carnitine: Facilitates the transport of fatty acids into mitochondria for energy production and may improve sperm motility.
- Lycopene: A potent antioxidant that protects cells from oxidative stress.
- Selenium: Essential for selenoprotein synthesis, contributing to antioxidant defense and thyroid hormone metabolism.
- Zinc: Plays a role in immune function, cell division, and protein synthesis. It’s crucial for male reproductive health.
- Folic Acid: Important for DNA synthesis and cell division, particularly during periods of rapid growth like spermatogenesis.
- Methylcobalamin: A form of Vitamin B12 involved in nerve function and red blood cell production.
- Fructo-oligosaccharides: Act as prebiotics, supporting the growth of beneficial gut bacteria.
- Citric Acid: Contributes to energy production through the Krebs cycle.
Pharmacokinetics: The absorption, metabolism, and elimination of each component vary:
- Coenzyme Q10: Absorbed with lipids, metabolized in the liver, and excreted in bile.
- Levo-carnitine: Absorbed in the small intestine, minimal hepatic metabolism, renal excretion.
- Lycopene: Absorbed with lipids, undergoes isomerization and metabolism in the liver, primarily excreted in bile and feces.
- Selenium: Absorbed from the small intestine, converted to selenoproteins, excreted in urine and feces.
- Zinc: Absorbed in the small intestine, bound to proteins, excreted mainly in feces.
- Folic Acid: Absorbed from the small intestine, metabolized in the liver, excreted in urine and bile.
- Methylcobalamin: Absorbed from the gastrointestinal tract, stored in the liver, and excreted in urine.
Dosage
Dosage recommendations for this specific combination may vary depending on the brand and formulation. It’s crucial to refer to the manufacturer’s instructions. Given the supplement nature, the dosage below refers to the values reported in one of the sources, reflecting a possible formulation for this combination. It is always best to consult with a healthcare professional for personalized advice.
Standard Dosage
Adults:
One sachet daily, dissolved in water, or as directed by the physician.
Children:
No specific dosage recommendations for children as this combination isn’t indicated for pediatric use.
Special Cases:
Dosage adjustments may be necessary based on individual patient factors, such as renal or hepatic impairment. Consult with a physician for specific guidance.
Clinical Use Cases
The provided sources do not specify dosages for specific clinical situations like intubation, surgical procedures, mechanical ventilation, ICU use, or emergency situations. This combination is not typically used in these settings.
Dosage Adjustments
Dosage modifications may be considered based on individual needs, including renal or hepatic dysfunction. Always consult a physician before making any adjustments.
Side Effects
Common Side Effects
Generally well-tolerated. Mild gastrointestinal discomfort like nausea or diarrhea might occur.
Rare but Serious Side Effects
Allergic reactions are possible. Seek immediate medical attention if any signs of allergy appear.
Long-Term Effects
No significant long-term adverse effects are anticipated with this combination.
Adverse Drug Reactions (ADR)
Rarely observed with these ingredients. Report any unusual symptoms to a physician.
Contraindications
No specific contraindications are listed in the sources. However, individuals with known hypersensitivity to any of the ingredients should avoid this combination.
Drug Interactions
Potential interactions with anticoagulants or certain medications metabolized by CYP enzymes are possible. Consult a healthcare professional before taking this supplement, especially if using other medications.
Pregnancy and Breastfeeding
Consult with a healthcare professional before using this supplement during pregnancy or breastfeeding.
Drug Profile Summary
- Mechanism of Action: Multifaceted: antioxidant protection, energy production, support for sperm health, etc.
- Side Effects: Generally well-tolerated, mild gastrointestinal issues possible.
- Contraindications: Hypersensitivity to any ingredient.
- Drug Interactions: Potential interactions with anticoagulants and drugs metabolized by CYP enzymes.
- Pregnancy & Breastfeeding: Consult with a healthcare professional before use.
- Dosage: Refer to product packaging or consult a physician.
- Monitoring Parameters: Semen analysis for infertility cases.
Popular Combinations
This combination is often used alone.
Precautions
Assess for any allergies or pre-existing conditions. Pregnant and breastfeeding women should consult with a physician.
FAQs (Frequently Asked Questions)
Q1: What is the recommended dosage for Citric Acid + Coenzyme Q10 + Folic Acid + Fructo Oligosaccharide + Levo-carnitine + Lycopene + Methylcobalamin + Selenium + Zinc?
A: Dosage may vary according to brand or as prescribed. Please check the product label or consult with a healthcare professional for personalized recommendations. One example found mentions one sachet dissolved in water daily.
Q2: What are the primary uses of this supplement?
A: Primarily used as a nutritional support for overall health, and often for male infertility, asthenozoospermia, and oligospermia.
Q3: Are there any known drug interactions I should be aware of?
A: Potential interactions may occur with anticoagulants and drugs metabolized by CYP enzymes. Always inform your physician about all other medications and supplements you are currently taking.
Q4: Can pregnant or breastfeeding women take this supplement?
A: Consult a physician before use during pregnancy or breastfeeding.
Q5: Are there any serious side effects associated with this combination?
A: Generally, it’s well-tolerated. However, rare allergic reactions are possible. Any signs of allergy should prompt immediate medical attention.
Q6: How does L-Carnitine contribute to the overall effect of this supplement?
A: L-carnitine assists in energy production by facilitating fatty acid transport into the mitochondria. It’s also believed to improve sperm count and motility.
Q7: What is the role of antioxidants like CoQ10, lycopene, and selenium in this supplement?
A: These antioxidants protect cells from damage caused by free radicals and oxidative stress, playing a crucial role in maintaining cellular health.
Q8: How does this supplement differ from a medication?
A: This is a nutritional supplement, not a classified drug. It aims to support overall health and address specific deficiencies rather than treat diseases.
Q9: What should I do if I experience any side effects while taking this supplement?
A: Discontinue use and consult with your physician immediately.
