Usage
This combination is primarily used as a dietary supplement to support overall health, particularly cardiovascular health, and to address nutritional deficiencies. It is not classified as a drug and lacks a specific pharmacological classification. The components work synergistically to provide antioxidant benefits, improve cardiovascular function, enhance energy production, and support immune function.
Alternate Names
This combination does not have a universally recognized international nonproprietary name (INN). It is typically referred to by its component names. Brand names vary depending on the manufacturer (e.g., Starich Q10, KQ-100, others).
How It Works
Pharmacodynamics:
- Coenzyme Q10 (CoQ10): Essential for mitochondrial function and energy production. Acts as an antioxidant, protecting cells from oxidative stress.
- L-Arginine: Precursor to nitric oxide, promoting vasodilation and improving blood flow. May also stimulate growth hormone release.
- Lycopene: A potent antioxidant carotenoid, protecting cells from damage caused by free radicals.
- Omega-3 Fatty Acids: Exhibit anti-inflammatory effects and may improve lipid profiles, contributing to cardiovascular health.
- Selenium Dioxide: Essential trace mineral with antioxidant properties, supporting immune function and protecting against cell damage.
Pharmacokinetics: Absorption, metabolism, and elimination data for this specific combination are not readily available. Information on individual components suggests oral absorption with varying bioavailability. CoQ10 is metabolized in the liver, L-arginine primarily in the liver and kidneys, lycopene is absorbed with fats and metabolized in the liver, omega-3 fatty acids are absorbed in the small intestine, and selenium is excreted in urine and feces. Specific CYP enzyme involvement and elimination pathways for the combined product require further investigation.
Dosage
Dosage recommendations for this combination are not standardized. It is crucial to consult with a physician for personalized guidance.
Standard Dosage
Adults:
Standard dosing guidelines are not established for this combination. Individual component dosages are often found on product labels, typically based on dietary reference intakes.
Children:
Due to the lack of established pediatric dosing and safety data, this combination is generally not recommended for children unless under explicit medical supervision.
Special Cases:
- Elderly Patients / Patients with Renal Impairment / Patients with Hepatic Dysfunction / Patients with Comorbid Conditions: Dosage adjustments should be made in consultation with a physician, considering the patient’s specific health status and potential drug interactions.
Clinical Use Cases
Dosage recommendations for specific clinical situations like intubation, surgical procedures, mechanical ventilation, ICU use, or emergency situations are not established for this combination.
Dosage Adjustments
Dose modification may be necessary based on individual patient characteristics, including renal or hepatic function and comorbid conditions. Consultation with a physician is essential for determining appropriate adjustments.
Side Effects
Common Side Effects
- Upset stomach
- Nausea
- Diarrhea
- Headache
- Dizziness
Rare but Serious Side Effects
- Bleeding tendencies (with high doses of Omega-3 fatty acids)
- Selenium toxicity (hair loss, brittle nails)
Long-Term Effects
Long-term effects of this combination have not been extensively studied.
Adverse Drug Reactions (ADR)
Significant ADRs are not typically reported, but allergic reactions to any component are possible.
Contraindications
- Hypersensitivity to any of the components.
Drug Interactions
- May interact with blood thinners (especially Omega-3 fatty acids).
- Potential interactions with certain antibiotics, antirheumatics, anticancer drugs, and antihypertensives.
- Consult a physician regarding potential interactions with other medications or supplements.
Pregnancy and Breastfeeding
The safety of this combination during pregnancy and breastfeeding has not been established. Consult with a physician before use.
Drug Profile Summary
- Mechanism of Action: See “How It Works” section above.
- Side Effects: See “Side Effects” section above.
- Contraindications: See “Contraindications” section above.
- Drug Interactions: See “Drug Interactions” section above.
- Pregnancy & Breastfeeding: Consult a physician; safety not established.
- Dosage: Consult a physician for personalized dosing recommendations.
- Monitoring Parameters: Monitor for any adverse effects and consult with a physician if they occur.
Popular Combinations
No specific combinations are recommended.
Precautions
- Consult with a physician before use, especially if pregnant, breastfeeding, or have pre-existing medical conditions.
- Discontinue use and seek medical attention if any adverse reactions occur.
FAQs (Frequently Asked Questions)
Q1: What is the recommended dosage for Coenzyme Q10 + L-Arginine + Lycopene + Omega-3 fatty acid + Selenium dioxide?
A: There’s no standardized dosage. Consult a doctor for personalized advice.
Q2: Is this combination safe during pregnancy?
A: Safety during pregnancy hasn’t been established. Consult a doctor.
Q3: Can I take this with other medications?
A: Potential drug interactions exist. Consult a physician before combining with any other medications, including OTC drugs and supplements.
Q4: Are there any long-term effects of taking this combination?
A: Long-term effects haven’t been extensively studied.
Q5: What should I do if I experience side effects?
A: Stop taking the supplement and consult a doctor.
Q6: Is this combination FDA approved?
A: This is considered a dietary supplement, not a drug, therefore not subject to FDA approval.
Q7: Can this combination replace prescribed medications for heart conditions?
A: No, it’s a supplement, not a medication replacement. Consult your doctor.
Q8: What are the main benefits of this combination?
A: It aims to support cardiovascular health, provide antioxidant benefits, enhance energy production, and potentially improve overall health.
Q9: Where can I buy this supplement?
A: This supplement is usually available in pharmacies and online. However, it’s essential to choose reputable sources and check the ingredients.
