Folic Acid + Iron + Lysine + Vitamin B12

Usage

This combination is prescribed for the treatment and prevention of nutritional deficiencies, particularly iron-deficiency anemia, and conditions with increased nutritional demands like pregnancy. It also aids in improving metabolism, promoting growth, and enhancing appetite. It is classified as a nutritional supplement. The combined action of its components addresses various deficiencies and supports essential bodily functions.

Alternate Names

There is no single international nonproprietary name (INN) for this specific combination product. Names reflect the included components.

How It Works

Pharmacodynamics: Iron is crucial for hemoglobin synthesis and oxygen transport. Vitamin B12 is essential for DNA synthesis, red blood cell formation, and nerve function. Folic acid plays a vital role in DNA and RNA synthesis and cell division. Lysine is an essential amino acid that aids in protein synthesis and nutrient utilization.

Pharmacokinetics: Iron absorption is enhanced by vitamin C and occurs primarily in the duodenum and upper jejunum. Vitamin B12 absorption requires intrinsic factor and occurs in the ileum. Folic acid is absorbed in the small intestine. Lysine is absorbed in the small intestine via active transport. Iron is primarily excreted in feces and small amounts via urine and sweat. Vitamin B12 is primarily excreted in bile. Folic acid is excreted in urine and feces. Lysine metabolism occurs primarily in the liver.

Mode of Action: Iron is incorporated into heme, a component of hemoglobin. Vitamin B12 acts as a cofactor for enzymes involved in DNA synthesis. Folic acid is converted to tetrahydrofolic acid, a cofactor for enzymes in purine and pyrimidine synthesis. Lysine participates in various metabolic pathways and enhances calcium absorption.

Dosage

Standard Dosage

Adults: Dosages are dependent on individual patient need and formulation of this combination supplement. General recommendation: 1 tablet or capsule daily, or as directed by a physician. Liquid formulations may be recommended, typically 5-15 ml daily.

Children: Dosages are dependent on individual patient need and formulation of this combination supplement and should be determined by a pediatrician. Liquid formulations or chewable tablets are generally used, with adjusted doses based on age and weight.

Special Cases:

• Elderly Patients: Consider potential for reduced absorption and adjust dosage as needed.
• Patients with Renal Impairment: Dose adjustments based on creatinine clearance may be necessary for certain formulations.
• Patients with Hepatic Dysfunction: Careful monitoring is recommended.
• Patients with Comorbid Conditions: Evaluate the need for dose adjustments based on individual patient needs.

Clinical Use Cases

Dosage in these cases is not standardized and should be based on individual patient needs and clinical judgment. Iron, folic acid, and vitamin B12 supplementation may be given based on deficiency and clinical response. Supplementation is usually oral unless malabsorption is present.

Dosage Adjustments

Adjust based on patient-specific factors including renal/hepatic function and comorbid conditions. Monitor iron levels, vitamin B12 levels, and complete blood count to optimize therapy.

Side Effects

Common Side Effects

• Nausea
• Constipation
• Diarrhea
• Dark stools
• Stomach upset

Rare but Serious Side Effects

• Allergic reactions (rash, itching, swelling)

Long-Term Effects

Generally safe for long-term use when taken as directed. However, excessive iron intake can lead to iron overload.

Adverse Drug Reactions (ADR)

Anaphylaxis (rare).

Contraindications

• Hypersensitivity to any of the components
• Hemochromatosis
• Hemosiderosis
• Hemolytic anemia

Drug Interactions

• Antacids: Can decrease iron absorption
• Antibiotics (tetracyclines, quinolones): Can interfere with absorption of both iron and the antibiotics
• Levothyroxine: Iron can reduce levothyroxine absorption.
• Levodopa: Iron can decrease levodopa’s effectiveness.

Pregnancy and Breastfeeding

Generally considered safe during pregnancy and breastfeeding. Folic acid is particularly important during pregnancy for neural tube development. Consult a healthcare professional for dosage recommendations.

Drug Profile Summary

Refer to individual sections for detailed explanations.

Popular Combinations

Frequently combined with other B vitamins (B1, B2, B3, B5, B6) and minerals (zinc).

Precautions

• Assess for deficiencies before initiating therapy.
• Monitor for potential side effects.
• Caution in patients with a history of gastrointestinal disorders.

FAQs (Frequently Asked Questions)

Q1: What is the recommended dosage for Folic Acid + Iron + Lysine + Vitamin B12?

A: Dosage depends on the individual product and patient-specific factors. Consult a physician for guidance.

Q2: Can this combination be given during pregnancy?

A: Yes, and it often is, particularly for the folic acid content, which is essential for preventing neural tube defects.

Q3: What are the common side effects?

A: Nausea, constipation, diarrhea, dark stools, and stomach upset.

Q4: Are there any drug interactions to be aware of?

A: Yes, antacids, some antibiotics, levothyroxine, and levodopa can interact with this combination.

Q5: How is this combination beneficial for anemia?

A: It provides iron for hemoglobin production, vitamin B12 and folic acid for red blood cell formation.

Q6: What is the role of lysine in this combination?

A: Lysine aids protein synthesis and nutrient utilization, which can support overall health and growth.

Q7: Can this combination be used long-term?

A: Generally safe for long-term use when taken as directed. Monitor iron levels to avoid iron overload.

Q8: Are there any contraindications for this combination?

A: Yes, hypersensitivity to any components, hemochromatosis, hemosiderosis, and hemolytic anemia are contraindications.

Q9: Is this combination available as a liquid?

A: Yes, liquid formulations and syrups are available, often for children or those with difficulty swallowing pills.