Usage
This combination medication is primarily prescribed for dry skin conditions such as xerosis, ichthyosis, and cracked heels. It is also used to manage rough, scaly, or itchy skin and minor skin irritations. It may be used for certain skin conditions like eczema, psoriasis, and ichthyosis vulgaris, but with caution, as it might exacerbate irritation in some cases. This topical medication falls under the pharmacological classifications of emollients and keratolytics, specifically categorized as a skin hydration medication. The mechanism of action involves the synergistic effects of its components to hydrate, exfoliate, and protect the skin.
Alternate Names
This combination doesn’t have a standardized International Nonproprietary Name (INN). It is often referred to by the names of its constituents. Some brand names under which this combination is marketed include HumaTant Cream, Moisturex Cream, Urelact Cream, Eurosoft Crack Heal, Moistril Cream, Keratovin Cream, Foot Mark Cream, Emlosoft Foot Cream, and Amaize Cream.
How It Works
Pharmacodynamics: The combined action of the ingredients addresses dry skin conditions through multiple mechanisms. Lactic acid, an alpha-hydroxy acid (AHA), exfoliates by dissolving the bonds between dead skin cells, promoting skin cell renewal and smoother skin. Liquid paraffin forms a protective barrier on the skin, preventing moisture loss and maintaining hydration. Propylene glycol, a humectant, draws moisture from the environment to the skin, keeping it hydrated and supple. Additionally, it enhances the penetration of other ingredients into the skin. Urea, a keratolytic agent, softens and hydrates the skin by breaking down keratin in dead skin cells, thus promoting exfoliation and hydration.
Pharmacokinetics: As a topical medication, systemic absorption is minimal. The ingredients primarily exert their effects locally on the skin.
Mode of Action: Lactic acid acts on the stratum corneum by disrupting the cohesion of corneocytes, leading to exfoliation. Liquid paraffin forms a hydrophobic layer on the skin’s surface, preventing transepidermal water loss. Propylene glycol increases skin hydration by drawing water into the stratum corneum. Urea increases the water-holding capacity of the stratum corneum and promotes desquamation of the skin.
Receptor binding, enzyme inhibition, or neurotransmitter modulation: The combination does not exhibit any known direct interactions with cellular receptors, inhibit specific enzymes, or modulate neurotransmitter activity. Its action is primarily focused on the physical and chemical properties of the skin layers.
Elimination pathways: Due to minimal systemic absorption, the elimination pathways for the topically applied medication are not clinically significant. Any small amounts absorbed are likely metabolized and excreted via typical routes.
Dosage
Standard Dosage
Adults:
Apply a thin layer to the affected area once or twice daily, or as directed by a physician.
Children:
Consult a pediatrician for appropriate dosing based on age and weight. Use with caution in children.
Special Cases:
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Elderly Patients: Generally, the standard dosage applies. Closely monitor for skin irritation.
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Patients with Renal Impairment: Use with caution, especially on large areas. Consult a physician.
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Patients with Hepatic Dysfunction: No specific dosage adjustments are typically required; however, monitor for adverse reactions.
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Patients with Comorbid Conditions: For eczema or psoriasis, use cautiously, as it might cause further irritation. Consult a physician.
Clinical Use Cases
This topical medication is not typically used in clinical settings such as intubation, surgical procedures, mechanical ventilation, ICU, or emergency situations. Its primary use is for managing dry skin conditions in outpatient settings.
Dosage Adjustments
Dosage adjustments might be necessary based on individual skin sensitivity. Reduce application frequency or discontinue use if irritation occurs. Consult a physician if symptoms persist.
Side Effects
Common Side Effects:
- Burning or stinging sensation at the application site
- Redness or itching
- Skin dryness
- Skin peeling or flaking
- Tingling
Rare but Serious Side Effects:
- Severe allergic reactions (seek immediate medical attention)
Long-Term Effects:
No specific long-term adverse effects have been reported with regular use. However, individual reactions may vary.
Adverse Drug Reactions (ADR):
Severe skin irritation or allergic reactions necessitate immediate medical attention.
Contraindications
- Known hypersensitivity or allergy to any of the ingredients
- Deep or puncture wounds
- Animal bites
- Serious burns
- Application to open wounds or broken skin
Drug Interactions
May interact with:
- Other exfoliating agents (e.g., salicylic acid, glycolic acid)
- Corticosteroids (e.g., hydrocortisone)
- Topical retinoids (e.g., tretinoin)
- Topical medications like beclamethasone
- Other emollients (e.g., petrolatum, lanolin)
- Moisturizers (e.g., glycerin, hyaluronic acid)
- Oral medications affecting skin condition (e.g., isotretinoin, minocycline)
These interactions can potentially increase skin irritation or alter skin barrier function.
Pregnancy and Breastfeeding
Consult a physician before use during pregnancy and breastfeeding, as safety has not been fully established. Information regarding the use of this medication during pregnancy and breastfeeding is limited.
Drug Profile Summary
- Mechanism of Action: Exfoliates dead skin cells, enhances moisture retention, softens skin.
- Side Effects: Burning, stinging, redness, itching, dryness, peeling.
- Contraindications: Hypersensitivity, open wounds, burns, deep wounds.
- Drug Interactions: Other exfoliants, corticosteroids, retinoids.
- Pregnancy & Breastfeeding: Consult physician before use.
- Dosage: Apply a thin layer once or twice daily.
- Monitoring Parameters: Observe for skin irritation or allergic reactions.
Popular Combinations
No specific popular combinations are listed for this drug. It is often used as a stand-alone treatment.
Precautions
- General Precautions: Perform a patch test for allergies; avoid open wounds.
- Pregnant Women: Consult a physician.
- Breastfeeding Mothers: Consult a physician.
- Children & Elderly: Use with caution.
- Menstruating Individuals: No specific precautions.
- Lifestyle Considerations: No specific restrictions related to alcohol, smoking, diet or driving.
FAQs (Frequently Asked Questions)
Q1: What is the recommended dosage for Lactic Acid + Liquid Paraffin + Propylene Glycol + Urea?
A: Apply a thin layer to the affected area once or twice daily, or as directed by a physician. For children, consult a pediatrician.
Q2: Can this product be used on the face?
A: It is not recommended to use this product on the face without consulting a doctor, as facial skin is more sensitive.
Q3: How long does it take to see results?
A: Initial improvements may appear within a few days. Full results can take 1 to 4 weeks, depending on the skin condition and usage.
A: Yes, but wait 5–10 minutes for the product to be absorbed before applying sunscreen.
Q5: What can I do to manage dry skin effectively?
A: Stay hydrated by drinking plenty of water. Avoid hot baths and use lukewarm water instead. Protect your skin from the sun by using sunscreen with at least SPF 15 or protective clothing. Moisturize immediately after bathing, and use gentle soaps, avoiding harsh products with strong scents.
Q6: What are common symptoms of dry skin?
A: Itching, scaling, cracking, or peeling are common dry skin symptoms. Severe cases can cause bleeding from cracked areas.
Q7: Does drinking alcohol cause dry skin?
A: Yes, excessive alcohol consumption can dehydrate, leading to rough, flaky, and itchy skin.
Q8: Can stress lead to dry skin?
A: Yes, stress can worsen skin conditions, making the skin appear older, less hydrated, and less healthy over time.
Q9: Can I use other skincare products with this medication?
A: Yes, but apply this medication first and allow it to absorb fully before applying other products.
Q10: Can I use this medication daily?
A: Yes, it can be used daily, as advised by your doctor, to maintain skin hydration and improve texture.
