Lidocaine + Liver Fraction 2 Derived From Fresh Liver 01

Usage

Lidocaine + Liver Fraction 2 Derived From Fresh Liver 01 is indicated for the treatment of liver disease. Lidocaine, a local anesthetic, offers pain relief. Liver Fraction 2, derived from animal livers, is a nutritional supplement that provides essential nutrients like vitamin B12, folic acid, and iron, supporting liver function and addressing pernicious anemia (vitamin B12 deficiency).

• Pharmacological Classification:

  • Lidocaine: Local anesthetic, Class IB antiarrhythmic.
  • Liver Fraction 2: Nutritional supplement.

• Mechanism of Action:

  • Lidocaine: Stabilizes neuronal membranes, inhibiting the ionic fluxes required for initiating and conducting nerve impulses. This effectively blocks nerve signals, reducing pain sensation.
  • Liver Fraction 2: Provides nutritional support crucial for liver health and function and helps treat pernicious anemia.

Alternate Names

• Lidocaine Hydrochloride + Liver Fraction 2 Derived From Fresh Liver 01
• Lignocaine + Liver Fraction 2 Derived From Fresh Liver 01
• Whole Liver Extra Injection (brand name according to some sources)

How It Works

• Pharmacodynamics:

  • Lidocaine: Blocks sodium channels in nerve fibers, thus inhibiting nerve impulse initiation and conduction, leading to local anesthesia.
  • Liver Fraction 2: Provides essential nutrients (vitamin B12, folic acid, iron) which promote liver health and function. It also helps in treating pernicious anemia by replenishing vitamin B12 levels.

• Pharmacokinetics:

  • Lidocaine: Rapid absorption following parenteral administration, metabolized mainly in the liver (primarily by CYP1A2 and CYP3A4), and excreted via kidneys (small amount remains unchanged). The half-life is roughly 1.5 to 2 hours, but can be extended in hepatic impairment.
  • Liver Fraction 2: Pharmacokinetic details are not specifically available.

• Mode of Action: Lidocaine acts by blocking sodium channels, which are essential for nerve impulse transmission. Liver Fraction 2 functions by providing nutritional support to the liver.

• Elimination Pathways: Lidocaine is mainly eliminated via hepatic metabolism with renal excretion of metabolites and a small amount of unchanged drug.

Dosage

This medication is administered intravenously by a healthcare professional. Self-administration is not recommended. Dosage is determined by the physician based on the individual patient’s condition and the severity of liver disease.

Standard Dosage

Information on standard dosage is not available in the provided sources. The dosage will be individualized to the patient.

Adults:

Dosage recommendations for adults are not specified in the available sources.

Children:

Pediatric dosing information is unavailable. However, caution is advised in children under 3 years old, using lidocaine only when other treatments are ineffective. Close monitoring is crucial due to potential toxicity.

Special Cases:

Dosage adjustments based on renal/hepatic dysfunction or comorbid conditions should be made under the guidance of a physician.

Clinical Use Cases

Dosage guidelines specific to clinical settings such as intubation, surgical procedures, or ICU use are not available in the provided sources.

Dosage Adjustments

Dose modifications will be determined by the physician based on individual patient factors, hepatic/renal function, and other medical conditions.

Side Effects

Common Side Effects

Limited data available. The sources do not mention common side effects for the combined medication.

Rare but Serious Side Effects

• Methemoglobinemia (Lidocaine): Symptoms include bluish or grayish skin discoloration, headache, rapid heart rate, shortness of breath, lightheadedness, and fatigue. Requires immediate medical intervention.

Long-Term Effects

Long-term effect information specific to this combination is not available.

Adverse Drug Reactions (ADR)

Clinically significant ADRs include methemoglobinemia (associated with lidocaine) and necessitate immediate intervention.

Contraindications

• Known hypersensitivity to lidocaine or amide-type local anesthetics.
• Severe liver disease.
• Certain heart conditions (e.g., heart block, severe shock).

Drug Interactions

• Medications that prolong the QT interval (e.g., certain antiarrhythmics, antibiotics) may increase the risk of cardiac arrhythmias when taken with lidocaine.
• Beta-blockers can reduce hepatic blood flow, thus potentially affecting lidocaine metabolism.
• CYP3A4 inhibitors and CYP1A2 inhibitors (e.g., some antifungals, macrolides) may decrease lidocaine clearance.
• Alcohol should be avoided, as it may exacerbate liver damage.

Pregnancy and Breastfeeding

• Pregnancy: Lidocaine’s safety during pregnancy isn’t fully established. Use cautiously and only if potential benefits exceed the risks.
• Breastfeeding: Lidocaine is considered safe while breastfeeding, as it passes into breast milk in minimal amounts. However, it’s crucial to discuss with your doctor before using any medication while breastfeeding.

Drug Profile Summary

• Mechanism of Action: Lidocaine blocks nerve signals; Liver Fraction 2 offers nutritional support.
• Side Effects: Limited data. Serious side effects: Methemoglobinemia (lidocaine).
• Contraindications: Hypersensitivity to lidocaine or amide-type anesthetics, severe liver disease, some heart conditions.
• Drug Interactions: Drugs prolonging QT interval, beta-blockers, CYP3A4 inhibitors, alcohol.
• Pregnancy & Breastfeeding: Lidocaine: Use with caution if pregnant. Safe during breastfeeding.
• Dosage: Determined by physician based on individual patient needs.
• Monitoring Parameters: Liver function tests, bilirubin levels, creatinine, blood/urine urea.

Popular Combinations

Specific information on frequently used drug combinations is not available.

Precautions

• General precautions: Pre-screening for allergies, organ dysfunction, and metabolic disorders.
• Specific populations: Consult a physician regarding dosage adjustments in elderly patients, children, and patients with liver disease.
• Lifestyle considerations: Avoid alcohol and smoking.

FAQs (Frequently Asked Questions)

Q1: What is the recommended dosage for Lidocaine + Liver Fraction 2 Derived From Fresh Liver 01?

A: The dosage is determined by the physician and individualized based on patient needs and the severity of liver disease.

Q2: How is this medication administered?

A: It is administered intravenously by a healthcare professional.

Q3: What is the role of lidocaine in this combination?

A: Lidocaine provides pain relief.

Q4: What is the function of Liver Fraction 2?

A: Liver Fraction 2 provides nutritional support for liver function and helps address pernicious anemia.

Q5: What are the serious side effects to watch out for?

A: Methemoglobinemia (with lidocaine) is a rare but serious side effect.

Q6: Can this medication be used during pregnancy?

A: Consult a physician; lidocaine’s safety during pregnancy isn’t fully established.

Q7: Is it safe to use while breastfeeding?

A: Generally considered safe during breastfeeding, but minimal amounts may pass into breast milk. Consult with your doctor.

Q8: Are there any drug interactions I should be aware of?

A: Yes, several. Consult a physician for specific guidance based on individual patient medications.

Q9: Who should not take this medication?

A: Individuals with hypersensitivity to lidocaine or amide-type local anesthetics, severe liver disease, or certain heart conditions should not use this medicine.

Q10: What precautions should be taken before administering this drug?

A: Patient evaluation should include screening for allergies, assessing organ function, and considering other medications and medical conditions.