Pantothenic Acid + Thiamine + Vitamin B2 + Vitamin A + Vitamin D3

Usage

This combination of vitamins is prescribed for the prevention and treatment of deficiencies in these specific vitamins. It is particularly relevant for individuals with poor dietary intake, malabsorption syndromes, or increased requirements (e.g., pregnancy, lactation). While each vitamin has its own distinct role, they collectively contribute to energy metabolism, nervous system function, healthy skin and mucous membranes, immune function, and bone health.

This drug is classified as a vitamin supplement. Each component belongs to various pharmacological classifications: pantothenic acid and B vitamins are essential nutrients supporting metabolic processes, Vitamin A supports vision and epithelial health, and vitamin D plays a role in calcium metabolism.

The mechanism of action for this combination involves multiple pathways. Pantothenic acid is a precursor to coenzyme A, crucial for energy production and fatty acid metabolism. Thiamine (B1) is a coenzyme in carbohydrate metabolism. Riboflavin (B2) is involved in redox reactions, energy production, and cellular function. Vitamin A plays roles in vision, gene expression, and cellular differentiation. Vitamin D promotes calcium absorption and bone mineralization.

Alternate Names

This combination doesn’t have a specific international nonproprietary name (INN) as it’s a blend of individual vitamins. Brand names vary depending on the manufacturer and formulation. Look for names which include the names of the individual vitamins or mention “B complex” plus vitamins A and D.

How It Works

Pharmacodynamics: Each vitamin exerts distinct effects. Pantothenic acid, as part of coenzyme A, is essential for energy production and fatty acid synthesis. Thiamine is involved in carbohydrate metabolism and nerve function. Riboflavin plays a role in energy production and cellular function as a component of flavin adenine dinucleotide (FAD) and flavin mononucleotide (FMN). Vitamin A is crucial for vision, cell growth, and immune function. Vitamin D regulates calcium and phosphate metabolism, supporting bone health.

Pharmacokinetics: These vitamins are absorbed in the gastrointestinal tract. Pantothenic acid and B vitamins are water-soluble, with excess excreted in urine. Vitamin A and D are fat-soluble, stored in the liver and adipose tissue.

Mode of Action: Pantothenic acid forms coenzyme A, essential for numerous metabolic reactions. Thiamine, as thiamine pyrophosphate, is a cofactor for enzymes in carbohydrate metabolism. Riboflavin is a precursor to FAD and FMN, participating in electron transport chain. Vitamin A binds to retinoid receptors, modulating gene transcription. Vitamin D binds to vitamin D receptors, regulating calcium and phosphate homeostasis.

Elimination Pathways: B vitamins are primarily excreted renally. Vitamins A and D are metabolized in the liver and excreted in bile.

Dosage

Dosage depends on age, health status, and specific needs. Consult a healthcare professional for personalized recommendations.

Standard Dosage

Adults: The recommended daily allowance for adults varies depending on age and sex. Please refer to resources like the National Institutes of Health (NIH) or other relevant dietary guidelines.

Children: Pediatric dosing should be determined based on the child’s age and health status. Refer to pediatric dosage charts and consult a pediatrician for guidance.

Special Cases:

• Elderly Patients: Requirements may increase due to decreased absorption.
• Patients with Renal Impairment: Dosage adjustments may be necessary for water-soluble vitamins.
• Patients with Hepatic Dysfunction: Adjustments might be necessary for fat-soluble vitamins.
• Patients with Comorbid Conditions: Specific conditions may influence vitamin requirements.

Clinical Use Cases and Dosage Adjustments

The dosages for clinical use cases (Intubation, Surgical Procedures, Mechanical Ventilation, ICU Use, Emergency Situations) should be based on patient’s specific needs and determined by the treating physician. Dosage adjustments should always be made based on individual patient factors, including renal/hepatic dysfunction and other relevant conditions.

Side Effects

Common Side Effects: High doses of certain vitamins can cause gastrointestinal issues like diarrhea (pantothenic acid) or nausea.

Rare but Serious Side Effects: Rare hypersensitivity reactions can occur.

Long-Term Effects: Long-term excessive intake of fat-soluble vitamins (A and D) can lead to toxicity.

Adverse Drug Reactions (ADR): Hypersensitivity and gastrointestinal problems can occur.

Contraindications

Contraindications are generally specific to individual components. For example, certain forms of vitamin D may be contraindicated in patients with hypercalcemia.

Drug Interactions

Certain medications may interact with specific vitamins in this combination. For example, some antibiotics may interfere with vitamin K synthesis (although not present in this combination). Consult a physician or pharmacist to understand potential drug interactions specific to this product.

Pregnancy and Breastfeeding

This combination is generally considered safe during pregnancy and breastfeeding when taken at recommended doses. However, it’s always important to consult with a healthcare professional before taking any supplements during these periods.

Drug Profile Summary (See above for details)

Popular Combinations

This combination is often included in multivitamin formulations and B-complex preparations. Additional vitamins and minerals may be added based on specific needs.

Precautions (See above sections on Side Effects, Contraindications, and Drug Interactions)

FAQs (Frequently Asked Questions)

Q1: What is the recommended dosage for Pantothenic Acid + Thiamine + Vitamin A + Vitamin B2 + Vitamin D3?

A: Refer to the Dosage section above. Dosages vary significantly depending on age, individual needs, and specific formulations. Consultation with a healthcare professional is essential for determining the correct dose.

Q2: Can this combination be taken during pregnancy?

A: Generally yes, but always consult with a physician or obstetrician before taking any supplements during pregnancy.

Q3: Are there any drug interactions I should be aware of?

A: Yes, certain drugs may interact with specific vitamins. Provide a complete list of medications to a doctor or pharmacist for evaluation of potential interactions.

Q4: What are the signs of vitamin B1 deficiency?

A: Symptoms can include beriberi (affecting the nervous system or cardiovascular system), Wernicke-Korsakoff syndrome, and muscle weakness.

Q5: What are the signs of vitamin B2 deficiency?

A: Symptoms can include cheilosis (cracks at the corners of the mouth), glossitis (inflamed tongue), and skin problems.

Q6: Can I take this combination if I have kidney disease?

A: It depends on the specific kidney condition and the type of vitamins in the formulation. Consult a nephrologist for dosage adjustments.

Q7: What are the long-term effects of excessive vitamin A intake?

A: Chronic hypervitaminosis A can cause liver damage, bone problems, and birth defects.

Q8: What if I miss a dose?

A: Simply take the next dose as scheduled. Do not double up on doses.

Q9: How should this combination be stored?

A: Store as directed on the product label. Generally, vitamins should be stored in a cool, dry place away from direct sunlight.

Q10: What should I do if I experience side effects?

A: Stop taking the supplement and consult a physician if side effects are persistent or severe.