Usage
Diastase is a digestive enzyme, specifically an amylase, that breaks down starch into smaller sugar molecules like maltose. It is used to treat indigestion, dyspepsia, and other digestive disorders. Its pharmacological classification is digestive enzyme. It works by supplementing the body’s natural amylase, improving the digestion of carbohydrates.
Alternate Names
Diastase is also known as fungal diastase when derived from fungi. It’s sometimes combined with other enzymes like pepsin and marketed under brand names such as Aristozyme, Unienzyme, Vivadase, Ownzyme, and Alzyme.
How It Works
Pharmacodynamics: Diastase catalyzes the hydrolysis of alpha-1,4 glycosidic linkages in starch. This breaks down complex carbohydrates into simpler sugars (maltose and dextrins), making them easier to absorb in the small intestine. This process reduces the workload on the pancreas and can improve symptoms like bloating, gas, and indigestion.
Pharmacokinetics: Diastase is taken orally and acts locally in the digestive tract. It is not absorbed systemically. Information about its metabolism and elimination pathways is limited as it primarily acts within the digestive tract.
Mode of Action: Diastase binds to starch molecules and breaks the glycosidic bonds through hydrolysis, releasing smaller sugar molecules.
Receptor Binding/Enzyme Inhibition: Diastase does not have specific receptor binding or inhibitory effects outside its enzymatic action on starch.
Elimination Pathways: Diastase, being an enzyme, gets degraded in the gastrointestinal tract and is not subject to the typical pharmacokinetic processes of absorption, metabolism, and systemic elimination like other drugs.
Dosage
Standard Dosage
Special Cases:
- Elderly Patients: Dosage adjustments are typically not required. But dose adjustments based on individual needs may be made at the physician’s discretion.
- Patients with Renal Impairment: Dose modification is usually not needed as it acts locally and is not absorbed systemically.
- Patients with Hepatic Dysfunction: Dose modification is usually not needed as it acts locally and is not absorbed systemically.
- Patients with Comorbid Conditions: Consult a healthcare professional before use, especially with diabetes, pancreatic disorders or gastrointestinal conditions.
Clinical Use Cases Diastase is not typically used in clinical settings like intubation, surgical procedures, mechanical ventilation, or the ICU. Its use is primarily for digestive support.
Dosage Adjustments Dose adjustments are generally not needed for renal or hepatic impairment. However, individual factors might influence the dosage and should be assessed by a physician.
Side Effects
Common Side Effects
- Abdominal discomfort
- Nausea
- Diarrhea
- Stomach upset
Rare but Serious Side Effects
- Allergic reactions (rash, itching, swelling)
Long-Term Effects No specific long-term adverse effects have been reported.
Contraindications
- Hypersensitivity to diastase or any component of the formulation.
- Acute pancreatitis.
Drug Interactions
- May interact with acarbose and miglitol (antidiabetic drugs).
- Alcohol may exacerbate some digestive issues and should be avoided during the course of the treatment.
Pregnancy and Breastfeeding
Consult with a physician before use during pregnancy or while breastfeeding. Safety data in these situations is limited.
Drug Profile Summary
- Mechanism of Action: Breaks down starch into simpler sugars, aiding carbohydrate digestion.
- Side Effects: Generally well-tolerated. May cause mild gastrointestinal discomfort.
- Contraindications: Hypersensitivity, acute pancreatitis.
- Drug Interactions: Antidiabetic drugs (acarbose, miglitol).
- Pregnancy & Breastfeeding: Consult a physician before use.
- Dosage: Varies; typically 1-2 tablets or capsules or 5-10 ml of liquid after meals.
- Monitoring Parameters: Not routinely monitored.
Popular Combinations
Diastase is often combined with pepsin, simethicone, papain, and/or activated charcoal to enhance digestive effects.
Precautions
- General Precautions: Assess for allergies, pancreatic disorders or other gastrointestinal conditions before use.
- Specific Populations: Consult with a physician if pregnant, breastfeeding, or administering to children and elderly patients.
- Lifestyle Considerations: Limit alcohol consumption.
FAQs (Frequently Asked Questions)
Q1: What is the recommended dosage for Diastase?
A: The dosage varies with the product. Generally, 1-2 tablets/capsules or 5-10 ml of liquid after meals is recommended for adults, while pediatric dosing should be determined by a physician.
Q2: How does Diastase work?
A: Diastase breaks down complex carbohydrates (starch) into simpler sugars, improving their digestion and absorption.
Q3: What are the potential side effects of Diastase?
A: Diastase is generally well-tolerated. Mild side effects like abdominal discomfort, nausea, or diarrhea may occur.
Q4: Who should not take Diastase?
A: Individuals with hypersensitivity to diastase or acute pancreatitis should avoid it.
Q5: Can Diastase be taken during pregnancy or breastfeeding?
A: Consult a healthcare professional before use during pregnancy or breastfeeding.
Q6: Does Diastase interact with any other medications?
A: It may interact with antidiabetic medications like acarbose and miglitol.
Q7: What are the benefits of taking Diastase?
A: Diastase improves starch digestion, reducing symptoms of indigestion, bloating, and gas.
Q8: How should Diastase be stored?
A: Store according to the product labeling. Generally store in a cool, dry place away from direct sunlight.
Q9: Can I take Diastase with other digestive enzymes?
A: Consult a healthcare professional for personalized advice. Diastase is often combined with other digestive enzymes in commercial formulations.
Q10: Are there any dietary restrictions while taking Diastase?
A: No specific dietary restrictions are typically necessary. However, maintaining a healthy diet is always recommended.
