Usage
Extractum Cepae-Cepalin, in combination with heparin and allantoin, is a topical dermatological agent primarily used for the management of scars. These scars can result from surgery, burns, stretch marks, acne, and breast amputations. It is also used for the treatment of burns, hypertrophic and keloidal scars, contractures (e.g., Dupuytren’s contracture, traumatic tendon contracture), and cicatricial strictures. It acts as an anti-inflammatory, antibacterial, and counter-irritant.
Alternate Names
This combination product is marketed under various brand names including Thromboscar Gel, Scanil Gel, Contractubex, and Scarlite Gel.
How It Works
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Pharmacodynamics:
- Extractum Cepae-Cepalin: Inhibits Prostaglandin F2-alpha (PGF2-alpha), reducing inflammation and scar tissue formation.
- Heparin: Acts as an anti-inflammatory, improves blood flow to the affected area, promotes healing, and aids in moisture retention within the scar tissue.
- Allantoin: Keratolytic agent that removes dead skin cells, softens the skin, and promotes wound healing.
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Pharmacokinetics: Topical application minimizes systemic absorption. Specific information on absorption, metabolism, and elimination pathways for this combination product is limited.
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Mode of Action: The combined action of these three components contributes to the overall effect of reducing inflammation, promoting healing, and improving scar appearance.
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Receptor Binding, Enzyme Inhibition, or Neurotransmitter Modulation: Extractum Cepae-Cepalin primarily inhibits PGF2-alpha. The mechanism of action for heparin and allantoin in scar reduction are less specific but contribute to anti-inflammatory and wound healing processes.
Dosage
Standard Dosage
Adults: Apply a thin layer to the clean and dry affected area 1-2 times daily or as directed by the physician. Gently massage until absorbed.
Children: Use in children under 1 year of age is not recommended. For children over 1 year, consult a pediatrician for appropriate dosage and application guidelines.
Special Cases:
- Elderly Patients: No specific dose adjustments are typically necessary. However, consider skin fragility and potential for irritation.
- Patients with Renal Impairment: No specific dose adjustments are necessary for topical application as systemic absorption is minimal.
- Patients with Hepatic Dysfunction: No specific dose adjustments are necessary for topical application as systemic absorption is minimal.
- Patients with Comorbid Conditions: While no specific adjustments are mentioned, caution is advised for patients with bleeding disorders or those taking anticoagulants. Consult a physician for personalized advice.
Clinical Use Cases
The provided sources primarily focus on scar management and wound healing. Dosage recommendations for specific clinical settings like intubation, surgical procedures, mechanical ventilation, ICU use, and emergency situations are not available. It is not typically used in these scenarios.
Dosage Adjustments
No specific dosage modifications based on patient factors are detailed in the sources. For any concurrent medications, underlying skin conditions, or specific concerns, physician consultation is recommended.
Side Effects
Common Side Effects
- Itching
- Redness (erythema)
- Tingling sensation
- Mild burning sensation upon application
- Skin irritation
Rare but Serious Side Effects
- Allergic reactions (e.g., rash, hives, difficulty breathing)
- Severe skin irritation or inflammation
Long-Term Effects
No specific long-term side effects from prolonged topical use are documented.
Adverse Drug Reactions (ADR)
Clinically significant ADRs requiring immediate intervention are rare. If severe allergic reactions or skin reactions occur, discontinue use and seek immediate medical attention.
Contraindications
- Hypersensitivity to any of the ingredients (allantoin, heparin sodium, extractum cepae-cepalin, or parabens).
- Open or unhealed wounds.
- Application to mucous membranes (eyes, nose, mouth, genitals).
- Infants under 1 year of age.
Drug Interactions
Limited information is available on specific drug interactions. However, caution is advised when using this product with other topical medications. It is recommended to avoid using other topical creams concurrently without consulting a doctor. No known drug-drug, drug-food, or drug-disease interactions.
Pregnancy and Breastfeeding
Pregnant and breastfeeding women should use this medication with caution. Consult a physician before use during pregnancy or breastfeeding.
Drug Profile Summary
- Mechanism of Action: Combination of anti-inflammatory, wound healing, and keratolytic actions.
- Side Effects: Itching, redness, tingling, burning sensation, skin irritation (common); allergic reactions, severe skin reactions (rare).
- Contraindications: Hypersensitivity to ingredients, open wounds, application to mucous membranes, infants under 1 year.
- Drug Interactions: Limited information available; caution advised with concurrent topical medications.
- Pregnancy & Breastfeeding: Use with caution; consult a physician.
- Dosage: Apply thinly to affected area 1-2 times daily.
- Monitoring Parameters: Observe for local skin reactions and allergic responses.
Popular Combinations
This product is typically used as a stand-alone topical treatment for scars. Information regarding popular combinations with other drugs is limited.
Precautions
- General Precautions: Avoid contact with eyes, nose, and mouth. Discontinue use if irritation occurs.
- Specific Populations (Pregnant Women, Breastfeeding Mothers, Children & Elderly): Use with caution in these populations and consult a physician before use.
FAQs (Frequently Asked Questions)
Q1: What is the recommended dosage for Extractum Cepae-Cepalin in combination with heparin and allantoin?
A: Apply a thin layer to the affected area 1-2 times daily, or as directed by your physician.
Q2: Can I use this product on open wounds?
A: No, this product should not be used on open or unhealed wounds.
Q3: Can I use this product if I am pregnant or breastfeeding?
A: Consult your physician before using this product if you are pregnant or breastfeeding.
Q4: What are the common side effects?
A: Common side effects include itching, redness, tingling, and mild burning or irritation at the application site.
Q5: What should I do if I experience a severe allergic reaction?
A: Discontinue use immediately and seek medical attention.
Q6: Can I use other topical creams along with this product?
A: Consult with your physician before using other topical medications concurrently.
Q7: How long does it take to see results?
A: Improvement in scar appearance varies depending on the individual and the type of scar. Consistent use as directed is essential.
Q8: Can this product be used on children?
A: It is not recommended for use in children under one year of age. Consult a pediatrician for guidance on use in older children.
Q9: Is it safe to use this product long-term?
A: No long-term side effects are documented, but consult your physician if you plan to use this product for an extended period.
Q10: What are the storage recommendations for this product?
A: Store below 30°C (86°F). Protect from moisture and light.
