Usage
Stabilized oxychloro complex (SOC), also known as Purite®, is primarily used as a preservative in ophthalmic solutions. It is not a medication itself but is included in formulations to prevent microbial contamination and prolong the shelf life of multi-dose eye drops. It is found in various eye drops prescribed for conditions like glaucoma, ocular hypertension, and dry eye. It does not have a pharmacological classification in the traditional sense (like antibiotic or analgesic) because it is not intended for therapeutic effect.
Alternate Names
- Purite®
- Stabilized oxychloro complex (SOC)
How It Works
Pharmacodynamics: Stabilized oxychloro complex exerts its preservative effect through oxidative processes. The exact mechanism is not fully elucidated, but it is thought to involve disruption of microbial cell membranes and interference with essential cellular functions, leading to microbial death. Its primary action is localized within the eye drop solution and on the ocular surface. Systemic absorption is minimal, resulting in negligible systemic effects.
Pharmacokinetics: Due to its minimal systemic absorption, detailed pharmacokinetic parameters (absorption, distribution, metabolism, and excretion) are not typically measured or relevant for stabilized oxychloro complex as a preservative.
Dosage
Stabilized oxychloro complex, being a preservative, does not have a specific dosage. Its concentration in ophthalmic solutions is determined by the manufacturer to ensure adequate preservation of the active ingredient(s) in the eye drops. The dosage of the active pharmaceutical ingredient (API) in the eye drops is determined independently of the preservative. Always follow the prescribed dosage for the specific eye drop product.
Standard Dosage
The dosage is determined by the active ingredient in the ophthalmic solution. Refer to the specific medication’s prescribing information for details. Stabilized oxychloro complex is present only in low concentrations as a preservative and does not contribute to the therapeutic dose.
Special Cases:
Dosage adjustments in special populations (elderly, renal/hepatic impairment, comorbid conditions) are determined by the active ingredient in the formulation, not the preservative.
Clinical Use Cases
The clinical use cases are determined by the active ingredient in the ophthalmic solution. Stabilized oxychloro is present as a preservative.
Dosage Adjustments
Dose modifications are based on the active ingredient in the eye drops, not the preservative.
Side Effects
Stabilized oxychloro complex is generally well-tolerated. However, some individuals may experience:
Common Side Effects
- Transient ocular irritation (burning, stinging)
- Blurred vision immediately after instillation (usually resolves quickly)
Rare but Serious Side Effects
- Allergic reactions (eyelid swelling, itching, redness) - discontinue use and seek medical attention if these occur
Long-Term Effects
Long-term effects of stabilized oxychloro complex as a preservative are not well-established, but chronic use is generally considered safe given its minimal systemic absorption.
Adverse Drug Reactions (ADR)
Clinically significant ADRs are rare. Allergic reactions require immediate discontinuation of the product and appropriate management.
Contraindications
- Known hypersensitivity to stabilized oxychloro complex
Drug Interactions
No significant drug interactions are expected with stabilized oxychloro complex itself. However, always consider potential interactions related to the active ingredient(s) in the specific ophthalmic solution.
Pregnancy and Breastfeeding
Limited data is available on the use of stabilized oxychloro complex during pregnancy and breastfeeding. Consult with a healthcare professional before using eye drops containing this preservative during these periods. The safety profile of the active pharmaceutical ingredient in the eye drop needs to be evaluated.
Drug Profile Summary
- Mechanism of Action: Antimicrobial preservative through oxidative processes.
- Side Effects: Transient ocular irritation, rare allergic reactions.
- Contraindications: Hypersensitivity.
- Drug Interactions: Generally, none expected from the preservative. Check specific eye drop formulation.
- Pregnancy & Breastfeeding: Limited data; consider risk-benefit ratio.
- Dosage: Determined by the active ingredient in the ophthalmic solution, not the preservative.
- Monitoring Parameters: Primarily observe for local ocular irritation or signs of allergic reactions.
Popular Combinations
Stabilized oxychloro complex is used as a preservative in ophthalmic solutions with various active ingredients. Examples include brimonidine tartrate for glaucoma and nepafenac for post-cataract surgery pain and inflammation.
Precautions
- General Precautions: Screen for known allergies to SOC. Exercise caution in individuals with a history of ocular sensitivities.
FAQs (Frequently Asked Questions)
Q1: What is the recommended dosage for Stabilized Oxychloro?
A: Stabilized oxychloro complex is a preservative and does not have its own dosage. The dosage is determined by the active drug in the eye drops.
Q2: What are the main uses of Stabilized Oxychloro?
A: It is used as a preservative to prevent microbial growth in multi-dose ophthalmic solutions.
Q3: Is Stabilized Oxychloro safe for long-term use?
A: Generally, yes. It is present in low concentrations and has minimal systemic absorption. However, monitor for local irritation or allergic reactions.
Q4: What should I do if I experience side effects?
A: Discontinue use and consult an ophthalmologist. Transient irritation is common, but allergic reactions warrant discontinuation.
Q5: Can I use eye drops with Stabilized Oxychloro if I’m pregnant or breastfeeding?
A: Consult your doctor. Limited data is available on its use during these periods. The safety profile of the active ingredient in the eye drops should also be considered.
Q6: Are there any known drug interactions with Stabilized Oxychloro?
A: No significant interactions are known for SOC itself. However, check for interactions with the active ingredient in the specific eye drops.
Q7: How does Stabilized Oxychloro work as a preservative?
A: It acts through oxidative processes, disrupting microbial cell membranes and functions.
Q8: Is Stabilized Oxychloro the same as benzalkonium chloride (BAK)?
A: No. They are different preservatives. SOC is generally considered less toxic to the ocular surface than BAK.
A: Generally, yes. However, consult your eye doctor for specific recommendations as some eye drops require removing contacts before instillation.
