Usage
- Streptococcus faecalis T-110 JPC is primarily prescribed for managing gastrointestinal disorders, including diarrhea (traveler’s, infantile, antibiotic-induced, and Clostridium difficile-associated), gastroenteritis, inflammatory bowel disease (IBD), and Helicobacter pylori eradication. It also aids in the treatment of dysbacteriosis and helps reduce symptoms in lactose-intolerant patients.
- Pharmacological Classification: Probiotic
- Mechanism of Action: S. faecalis T-110 JPC, a probiotic strain, works synergistically with other probiotics to restore and maintain a healthy balance of gut flora. It assists in breaking down complex carbohydrates and supports the growth of beneficial gut bacteria. It produces lactic acid, which helps maintain gut pH, creating an environment that suppresses the growth of harmful bacteria. This strain stimulates the immune system.
Alternate Names
- Enterococcus faecalis T-110 JPC
- Streptococcus faecalis T110 JPC (variant spelling)
- This strain is often found in combination probiotic products containing Clostridium butyricum, Bacillus mesentericus, and Lactobacillus sporogenes. Brand names include products such as Bifilac and Cronogut.
How It Works
- Pharmacodynamics: S. faecalis T-110 JPC exerts its effects by modulating the gut flora composition. It produces lactic acid, leading to an acidic environment that inhibits the growth of certain pathogenic bacteria. It supports the growth of beneficial gut bacteria, improving digestion and nutrient absorption. It also stimulates the immune system.
- Pharmacokinetics: As this is a live bacterial strain, its pharmacokinetics is different from traditional drugs. It is administered orally, usually as part of a combination product. While some metabolic activity can occur within the gastrointestinal tract, including breakdown of carbohydrates and production of lactic acid, minimal systemic absorption of the intact bacteria is expected. The primary mechanism of action is local within the gut. Elimination is primarily through fecal excretion.
- Mode of Action: S. faecalis T-110 JPC adheres to the intestinal lining and competes with pathogenic bacteria for resources and attachment sites. The production of lactic acid lowers gut pH, inhibiting the growth of pathogens. It does not have specific receptor binding, enzyme inhibition, or neurotransmitter modulation effects like traditional drugs.
Dosage
Standard Dosage
Children: Dosage should be determined by a pediatrician.
Clinical Use Cases
Information regarding specific dosages in clinical situations (intubation, surgery, mechanical ventilation, ICU use, or emergency situations) is not available.
Dosage Adjustments
Dosage modifications are based on individual patient factors and specific product formulation.
Side Effects
Common Side Effects
- Gas
- Bloating
- Abdominal discomfort
- Nausea
- Loss of appetite
- Constipation
- Diarrhea
- Flatulence
Rare but Serious Side Effects
- Infections (particularly in immunocompromised individuals)
Long-Term Effects
No specific long-term adverse effects have been reported.
Adverse Drug Reactions (ADR)
- Severe allergic reactions (rare)
Contraindications
- Hypersensitivity to any component of the product
Drug Interactions
- Antibiotics: Concurrent use may reduce the effectiveness of both the antibiotic and the probiotic. It’s generally recommended to administer probiotics at least two hours before or after antibiotics.
Pregnancy and Breastfeeding
The safety of S. faecalis T-110 JPC during pregnancy and breastfeeding has not been fully established. Consultation with a physician is recommended before use. While GBS is a concern during pregnancy and breastfeeding, S. faecalis T-110 JPC is a different strain and is generally considered safe, but caution should be taken.
Drug Profile Summary
- Mechanism of Action: Probiotic; modulates gut flora, produces lactic acid, and stimulates the immune system.
- Side Effects: Gas, bloating, abdominal discomfort, nausea, constipation, diarrhea, and flatulence. Rarely, infections in immunocompromised individuals.
- Contraindications: Hypersensitivity.
- Drug Interactions: Antibiotics.
- Pregnancy & Breastfeeding: Consult a physician before use.
- Dosage: Varies depending on product formulation; consult product label or physician.
- Monitoring Parameters: Monitor for improvement in gastrointestinal symptoms.
Popular Combinations
Often combined with Clostridium butyricum, Bacillus mesentericus, and Lactobacillus sporogenes for synergistic effects in restoring gut flora.
Precautions
Consult a physician before using in patients with weakened immune systems, malnourishment, liver, or kidney problems.
FAQs (Frequently Asked Questions)
Q1: What is the recommended dosage for Streptococcus faecalis T-110 JPC?
A: The dosage varies depending on the specific product formulation. Always follow the instructions on the product label or consult a physician.
Q2: Can I take this probiotic with antibiotics?
A: It is generally recommended to separate the administration of probiotics and antibiotics by at least two hours.
Q3: How does this strain benefit lactose intolerance?
A: It helps reduce symptoms in lactose-intolerant patients by aiding in lactose breakdown.
Q4: Are there any serious side effects?
A: While generally safe, rare cases of infections have been reported, primarily in immunocompromised individuals.
Q5: Is it safe during pregnancy?
A: Safety during pregnancy and breastfeeding hasn’t been fully established. Consult a physician before use.
Q6: How does it differ from other probiotics?
A: It is noted for its lactic acid production, ability to break down complex carbohydrates, and synergistic support of other beneficial gut bacteria.
Q7: How long should I take it?
A: Continue taking it for as long as your doctor prescribes it, even if symptoms disappear.
Q8: What if I miss a dose?
A: If you miss a dose, take it as soon as you remember. If it’s almost time for the next dose, skip the missed dose.
Q9: Can it be given to a child?
A: It can be given to children if advised by a doctor. Consult a pediatrician for appropriate dosing.
