Usage
Triticum Vulgare extract, also known as wheat germ extract, is primarily used to treat skin conditions characterized by inflammation and itching, such as decubitus ulcers (bedsores), skin lesions, and burns. It is also used for vaginal inflammation, itching, and vulvar dystrophy, as well as in the treatment of vaginal yeast infections. Its pharmacological classification can be broadly categorized as an anti-inflammatory and emollient agent. The mechanism of action involves promoting skin repair by facilitating new tissue growth and reducing the production of inflammatory chemicals. It contains vitamin E, which acts as a skin conditioning agent. Additionally, Triticum Vulgare extract helps in wound healing and skin regeneration due to its antioxidant properties. When used for yeast infections, it helps alleviate symptoms like vaginal dryness, pain, burning, itching, and discharge. For dental application, it can improve gingival health and reduce plaque accumulation, effectively controlling gingival inflammation as an adjuvant treatment.
Alternate Names
- Wheat germ extract
- Triticum aestivum extract
- Oil of wheat germ
- Triticum aestivum germ oil
- Wheat germ oil
How It Works
Pharmacodynamics: Triticum Vulgare extract promotes tissue regeneration by increasing fibroblast and endothelial cell proliferation. It modulates the inflammatory response by reducing the expression of inflammatory mediators, such as IL-6, TNFα, prostaglandin E2, and nitric oxide. It enhances fibronectin production and its localization in the extracellular matrix, crucial for cell differentiation and migration during wound healing. Improves gingival health by reducing plaque accumulation and inflammation.
Pharmacokinetics: Detailed information regarding the absorption, metabolism, and elimination of topically applied Triticum Vulgare extract is limited. Systemic absorption is expected to be minimal. For intravaginal use, systemic effects have not been well-studied. The elimination pathways are not clearly defined. However, for oral use as a spray, after two weeks of daily use, no systemic side effects were observed.
Dosage
Dosing information for Triticum Vulgare extract for systemic use is limited. The available information mainly pertains to topical applications, intravaginal pessaries, or oral spray.
Standard Dosage
Adults:
- Topical: For creams or ointments, the concentration typically ranges from 3% to 15%. Follow product-specific instructions.
- Intravaginal: Pessaries containing 0.6 gm of Triticum Vulgare extract are available, usually one pessary applied deeply into the vagina in the evening, or as prescribed by a doctor.
- Dental Spray: Twice daily after tooth brushing.
- Oral: limited studies exist for Avemar brand of fermented wheat germ extract up to 9 g twice daily, generally well tolerated, possible side effects include nausea and diarrhea.
Children:
Pediatric dosing guidelines are not established. Consult a healthcare professional.
Special Cases:
Dosage adjustments for special populations are not clearly defined due to the lack of systemic dosing guidelines. Consult a healthcare professional for guidance in these cases.
Clinical Use Cases
Dosage recommendations for specific clinical settings (e.g., intubation, surgical procedures, mechanical ventilation, ICU use, emergency situations) are not established.
Dosage Adjustments
Dosage modifications based on patient-specific factors are not well-defined due to limited information on systemic use.
Side Effects
Common Side Effects
- Burning sensation
- Irritation
- Itching at the application site
Rare but Serious Side Effects
Limited data available. Report any unusual reactions to a healthcare professional.
Long-Term Effects
Limited data available.
Adverse Drug Reactions (ADR)
Limited data available.
Contraindications
- Known allergy to wheat or any components of the product.
Drug Interactions
Limited information is available on drug interactions. It’s advisable to inform the doctor about all other medications, including vitamins and herbal supplements, before using Triticum Vulgare extract.
Pregnancy and Breastfeeding
Limited studies are available on the use of Triticum Vulgare extract during pregnancy and breastfeeding. Consult a healthcare professional for guidance. It is not known if it is excreted in breast milk.
Drug Profile Summary
- Mechanism of Action: Promotes skin repair, reduces inflammation, enhances fibronectin production.
- Side Effects: Burning sensation, irritation, itching at the application site.
- Contraindications: Hypersensitivity to wheat or any components of the product.
- Drug Interactions: Limited data available. Advise patients to inform their doctor of all medications they are taking.
- Pregnancy & Breastfeeding: Limited data available. Consult a healthcare professional.
- Dosage: See detailed dosage section above.
- Monitoring Parameters: Monitor the affected area for signs of improvement or adverse reactions.
Popular Combinations
No established popular combinations are available for Triticum Vulgare extract.
Precautions
- Pre-screening for wheat allergy is essential.
- Monitor the affected area for any signs of irritation or allergic reaction.
- Pregnant or breastfeeding women should consult a healthcare professional before use.
- Exercise caution in patients with liver or kidney disease.
FAQs (Frequently Asked Questions)
A: The dosage varies depending on the formulation and the condition being treated. Refer to the dosage section above for more information. Consult a doctor for appropriate dosage and administration.
A: Limited data are available regarding its use during pregnancy. Consult a healthcare professional before use.
A: Common side effects include burning sensation, irritation, and itching at the application site.
A: It promotes skin repair, reduces inflammation, and supports tissue regeneration.
A: Limited information is available on drug interactions. It’s important to inform your doctor about all medications you are taking before using this product.
A: Pediatric dosing guidelines are not established. Consult a healthcare professional.
A: It can help to decrease the severity of yeast infection symptoms. However, if symptoms persist, consult a doctor.
A: Yes, it can be used on open wounds like skin lesions, burns, and bedsores.
A: It is effective in controlling gingival inflammation when used in conjunction with regular brushing and flossing.
